Synthesis of azaphenanthridines via anionic ring closure

TY - JOUR

T1 - Synthesis of azaphenanthridines via anionic ring closure

AU - Hansen, Henriette Møller

AU - Lysén, M.

AU - Begtrup, M.

AU - Kristensen, Jesper Langgaard

PY - 2005/10/17

Y1 - 2005/10/17

N2 - A new and convergent synthesis of azaphenanthridines via an anionic ring closure is reported. Ortho-lithiation/in situ borylation of cyanopyridines produces the corresponding cyanopyridylboronic esters, which undergo a Suzuki-Miyaura cross-coupling to give the key intermediates. Addition of lithium morpholide produces the azaphenanthridines.

AB - A new and convergent synthesis of azaphenanthridines via an anionic ring closure is reported. Ortho-lithiation/in situ borylation of cyanopyridines produces the corresponding cyanopyridylboronic esters, which undergo a Suzuki-Miyaura cross-coupling to give the key intermediates. Addition of lithium morpholide produces the azaphenanthridines.

UR - http://www.scopus.com/inward/record.url?scp=24944474804&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2005.08.051

DO - 10.1016/j.tet.2005.08.051

M3 - Journal article

AN - SCOPUS:24944474804

SN - 0040-4020

VL - 61

SP - 9955

EP - 9960

JO - Tetrahedron

JF - Tetrahedron

IS - 42

ER -