Synthesis, discovery, and quantitation of dihomo-Isofurans: Biomarkers for in vivo adrenic acid peroxidation

TY - JOUR

T1 - Synthesis, discovery, and quantitation of dihomo-Isofurans

T2 - Biomarkers for in vivo adrenic acid peroxidation

AU - de La Torre, Aurélien

AU - Lee, Yiu Yiu

AU - Oger, Camille

AU - Sangild, Per Torp

AU - Durand, Thierry

AU - Lee, Jetty Chung-Yung

AU - Galano, Jean-Marie

N1 - CURIS 2014 NEXS 161

PY - 2014/6/10

Y1 - 2014/6/10

N2 - The growing importance of lipidomics, and the interest of non-enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC-MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment.

AB - The growing importance of lipidomics, and the interest of non-enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC-MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment.

U2 - 10.1002/anie.201402440

DO - 10.1002/anie.201402440

M3 - Journal article

C2 - 24839059

SN - 1433-7851

VL - 53

SP - 6249

EP - 6252

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 24

ER -