Syndecan proteoglycans and cell adhesion.

TY - JOUR

T1 - Syndecan proteoglycans and cell adhesion.

AU - Woods, A

AU - Oh, E S

AU - Couchman, J R

N1 - Keywords: Amino Acid Sequence; Animals; Cell Adhesion; Cell Membrane; Cytoplasm; Cytoskeleton; Heparitin Sulfate; Humans; Membrane Glycoproteins; Molecular Sequence Data; Proteoglycans; Syndecans

PY - 1998

Y1 - 1998

N2 - It is now becoming clear that a family of transmembrane proteoglycans, the syndecans, have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration.

AB - It is now becoming clear that a family of transmembrane proteoglycans, the syndecans, have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration.

M3 - Journal article

C2 - 9881599

SN - 0945-053X

VL - 17

SP - 477

EP - 483

JO - Matrix Biology

JF - Matrix Biology

IS - 7

ER -