Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma

Maria E Lendorf; Tina Manon-Jensen; Pauliina Kronqvist; Hinke A B Multhaupt; John R Couchman

doi:10.1369/0022155411405057

Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma

Maria E Lendorf, Tina Manon-Jensen, Pauliina Kronqvist, Hinke A B Multhaupt, John R Couchman

Nutritional Immunology

82 Citationer (Scopus)

Abstract

Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation. Their expression can also serve as prognostic markers. In breast carcinomas, syndecan-1 overexpression correlates with poor prognosis and aggressive phenotype. Syndecan-4 is expressed in most breast carcinoma cell lines, but its role in malignancy is unclear. A possible relationship between syndecan-1 and syndecan-4 expression and established prognostic factors in breast carcinomas was examined. Duplicate samples of 114 benign and malignant breast disease cases were stained for the two syndecans. Clinicopathological information was available for all cases. Syndecan-1 was detected in 72.8% of cases, with significant association between its expression and histological tumor type (p

Originalsprog	Engelsk
Tidsskrift	Journal of Histochemistry and Cytochemistry
Vol/bind	59
Udgave nummer	6
Sider (fra-til)	615-29
Antal sider	15
ISSN	0022-1554
DOI	https://doi.org/10.1369/0022155411405057
Status	Udgivet - 1 jun. 2011

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10.1369/0022155411405057

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title = "Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma",

abstract = "Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation. Their expression can also serve as prognostic markers. In breast carcinomas, syndecan-1 overexpression correlates with poor prognosis and aggressive phenotype. Syndecan-4 is expressed in most breast carcinoma cell lines, but its role in malignancy is unclear. A possible relationship between syndecan-1 and syndecan-4 expression and established prognostic factors in breast carcinomas was examined. Duplicate samples of 114 benign and malignant breast disease cases were stained for the two syndecans. Clinicopathological information was available for all cases. Syndecan-1 was detected in 72.8% of cases, with significant association between its expression and histological tumor type (p",

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author = "Lendorf, {Maria E} and Tina Manon-Jensen and Pauliina Kronqvist and Multhaupt, {Hinke A B} and Couchman, {John R}",

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T1 - Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma

AU - Lendorf, Maria E

AU - Manon-Jensen, Tina

AU - Kronqvist, Pauliina

AU - Multhaupt, Hinke A B

AU - Couchman, John R

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation. Their expression can also serve as prognostic markers. In breast carcinomas, syndecan-1 overexpression correlates with poor prognosis and aggressive phenotype. Syndecan-4 is expressed in most breast carcinoma cell lines, but its role in malignancy is unclear. A possible relationship between syndecan-1 and syndecan-4 expression and established prognostic factors in breast carcinomas was examined. Duplicate samples of 114 benign and malignant breast disease cases were stained for the two syndecans. Clinicopathological information was available for all cases. Syndecan-1 was detected in 72.8% of cases, with significant association between its expression and histological tumor type (p

AB - Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation. Their expression can also serve as prognostic markers. In breast carcinomas, syndecan-1 overexpression correlates with poor prognosis and aggressive phenotype. Syndecan-4 is expressed in most breast carcinoma cell lines, but its role in malignancy is unclear. A possible relationship between syndecan-1 and syndecan-4 expression and established prognostic factors in breast carcinomas was examined. Duplicate samples of 114 benign and malignant breast disease cases were stained for the two syndecans. Clinicopathological information was available for all cases. Syndecan-1 was detected in 72.8% of cases, with significant association between its expression and histological tumor type (p

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Breast Neoplasms

KW - Case-Control Studies

KW - Female

KW - Fluorescent Antibody Technique

KW - Humans

KW - Immunohistochemistry

KW - Middle Aged

KW - Syndecan-1

KW - Syndecan-4

KW - Tumor Markers, Biological

KW - Young Adult

U2 - 10.1369/0022155411405057

DO - 10.1369/0022155411405057

M3 - Journal article

C2 - 21430259

SN - 0022-1554

VL - 59

SP - 615

EP - 629

JO - Journal of Histochemistry and Cytochemistry

JF - Journal of Histochemistry and Cytochemistry

IS - 6

ER -

Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma

Abstract

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