TY - JOUR
T1 - Symptom profiles and executive function in childhood obsessive-compulsive disorder
AU - Hybel, Katja Anna
AU - Lykke Mortensen, Erik
AU - Højgaard, David R. M. A.
AU - Lambek, Rikke
AU - Hove Thomsen, Per
PY - 2017/7
Y1 - 2017/7
N2 - Obsessive-compulsive disorder (OCD) often becomes manifest in childhood. It has been suggested that the symptom heterogeneity of the disorder could mask subgroups associated with executive function (EF) impairment. Though supported in adult studies, this is scarcely investigated in children. The aims of the present study were to: (i) investigate OCD symptom subgroups using an empirically supported and age-appropriate definition of symptom dimensions (SD) as well as latent profile analysis (LPA); (ii) compare the identified subgroups with respect to EFs, demographic, and clinical descriptives; and (iii) explore the associations between SDs and EFs. The study included 50 pediatric OCD patients and 50 matched controls. Patients were assessed with the Children's Yale-Brown Obsessive-Compulsive Scale from which three SD factor scores were generated. Participants were assessed with EF tasks from which latent variables measuring working memory, set shifting and response inhibition were derived. Parents rated executive function behaviors in their children. Three subgroups were identified, each predominantly characterized by one of the SDs. Subgroups differed with respect to parent-rated working memory and several demographic and basic clinical characteristics. The findings suggest the presence of clinically relevant child and adolescent OCD SD subgroups, but do not support the relevance of EFs in distinguishing SDs.
AB - Obsessive-compulsive disorder (OCD) often becomes manifest in childhood. It has been suggested that the symptom heterogeneity of the disorder could mask subgroups associated with executive function (EF) impairment. Though supported in adult studies, this is scarcely investigated in children. The aims of the present study were to: (i) investigate OCD symptom subgroups using an empirically supported and age-appropriate definition of symptom dimensions (SD) as well as latent profile analysis (LPA); (ii) compare the identified subgroups with respect to EFs, demographic, and clinical descriptives; and (iii) explore the associations between SDs and EFs. The study included 50 pediatric OCD patients and 50 matched controls. Patients were assessed with the Children's Yale-Brown Obsessive-Compulsive Scale from which three SD factor scores were generated. Participants were assessed with EF tasks from which latent variables measuring working memory, set shifting and response inhibition were derived. Parents rated executive function behaviors in their children. Three subgroups were identified, each predominantly characterized by one of the SDs. Subgroups differed with respect to parent-rated working memory and several demographic and basic clinical characteristics. The findings suggest the presence of clinically relevant child and adolescent OCD SD subgroups, but do not support the relevance of EFs in distinguishing SDs.
KW - Children
KW - Executive function
KW - Latent profile analysis
KW - Obsessive-compulsive disorder
KW - Symptom dimension subgroups
U2 - 10.1016/j.jocrd.2017.05.003
DO - 10.1016/j.jocrd.2017.05.003
M3 - Journal article
AN - SCOPUS:85019188057
SN - 2211-3649
VL - 14
SP - 36
EP - 46
JO - Journal of Obsessive-Compulsive and Related Disorders
JF - Journal of Obsessive-Compulsive and Related Disorders
ER -