TY - JOUR
T1 - Sweet escape: sialic acids in tumor immune evasion
AU - Büll, Christian
AU - den Brok, Martijn H
AU - Adema, Gosse J
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2014/8
Y1 - 2014/8
N2 - Sialic acids represent a family of sugar molecules derived from neuraminic acid that frequently terminate glycan chains and contribute to many biological processes. Already five decades ago, aberrantly high expression of sialic acids has been proposed to protect cancer cells from recognition and eradication by the immune system. Today, increased understanding at the molecular level demonstrates the broad immunomodulatory capacity of tumor-derived sialic acids that is, at least in part, mediated through interactions with immunoinhibitory Siglec receptors. Here we will review current studies from a sialic acid sugar perspective showing that tumor-derived sialic acids disable major killing mechanisms of effector immune cells, trigger production of immune suppressive cytokines and dampen activation of antigen-presenting cells and subsequent induction of anti-tumor immune responses. Furthermore, strategies to modulate sialic acid expression in cancer cells to improve cancer immunotherapy will be discussed.
AB - Sialic acids represent a family of sugar molecules derived from neuraminic acid that frequently terminate glycan chains and contribute to many biological processes. Already five decades ago, aberrantly high expression of sialic acids has been proposed to protect cancer cells from recognition and eradication by the immune system. Today, increased understanding at the molecular level demonstrates the broad immunomodulatory capacity of tumor-derived sialic acids that is, at least in part, mediated through interactions with immunoinhibitory Siglec receptors. Here we will review current studies from a sialic acid sugar perspective showing that tumor-derived sialic acids disable major killing mechanisms of effector immune cells, trigger production of immune suppressive cytokines and dampen activation of antigen-presenting cells and subsequent induction of anti-tumor immune responses. Furthermore, strategies to modulate sialic acid expression in cancer cells to improve cancer immunotherapy will be discussed.
KW - Animals
KW - Complement System Proteins/immunology
KW - Dendritic Cells/immunology
KW - Humans
KW - Immune System/metabolism
KW - Immunotherapy
KW - Myeloid Cells/immunology
KW - Neoplasms/immunology
KW - Sialic Acids/metabolism
KW - T-Lymphocytes, Cytotoxic/immunology
KW - Tumor Escape/immunology
U2 - 10.1016/j.bbcan.2014.07.005
DO - 10.1016/j.bbcan.2014.07.005
M3 - Review
C2 - 25026312
SN - 0304-419X
VL - 1846
SP - 238
EP - 246
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 1
ER -
