SUVmax of 18FDG PET/CT as a predictor of high-risk endometrial cancer patients

Sofie Leisby Antonsen; Annika Loft; Rune Vincents Fisker; Anne Lerberg Nielsen; Erik Søgaard Andersen; Estrid Høgdall; Ann Tabor; Kirsten Væver Jochumsen; Carsten L Fagö-Olsen; Jon Asmussen; Anne Kiil Berthelsen; Ib Jarle Christensen; Claus Høgdall

doi:10.1016/j.ygyno.2013.01.019

SUVmax of 18FDG PET/CT as a predictor of high-risk endometrial cancer patients

Sofie Leisby Antonsen, Annika Loft, Rune Vincents Fisker, Anne Lerberg Nielsen, Erik Søgaard Andersen, Estrid Høgdall, Ann Tabor, Kirsten Væver Jochumsen, Carsten L Fagö-Olsen, Jon Asmussen, Anne Kiil Berthelsen, Ib Jarle Christensen, Claus Høgdall

Abstract

Objective: To evaluate SUVmax in the assessment of endometrial cancer preoperatively with particular focus on myometrial invasion (MI), cervical invasion (CI), FIGO stage, risk-stratification and lymph node metastases (LNM). Methods: A total of 268 women with endometrial cancer or atypical endometrial hyperplasia underwent FDG PET/CT imaging before surgical treatment. SUVmax of the primary tumour was compared with histological prognostic factors. Results: SUVmax was significantly higher in patients with high FIGO stages (p < 0.0001), deep MI (p = 0.002), CI (p = 0.04), LNM (p = 0.04) and high risk tumours (p = 0.003). Linear regression found that SUVmax was dependent of MI (p = 0.001, 95% CI 2.863-11.098), CI (p = 0.001, 95% CI 2.896-11.499), risk (p = 0.004, 95% CI 0.077-0.397), LNM (p = 0.04, 95% CI 0.011-0.482) and FIGO stage (p < 0.0001, 95% CI 0.158-0.473). Conclusions: Preoperative PET/CT scanning and SUVmax measurements of the primary tumour may provide additional clinical and prognostic information about MI, CI, LNM and high risk disease in patients with endometrial cancer and allow for individualization of patient care. However, the sensitivity and specificity of the SUVmax in staging endometrial cancer is not high enough to reliably replace surgical staging.

Originalsprog	Engelsk
Tidsskrift	Gynecologic Oncology
Vol/bind	129
Udgave nummer	2
Sider (fra-til)	298-303
Antal sider	6
ISSN	0090-8258
DOI	https://doi.org/10.1016/j.ygyno.2013.01.019
Status	Udgivet - maj 2013

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Antonsen, S. L., Loft, A., Fisker, R. V., Nielsen, A. L., Andersen, E. S., Høgdall, E., Tabor, A., Jochumsen, K. V., Fagö-Olsen, C. L., Asmussen, J., Berthelsen, A. K., Christensen, I. J., & Høgdall, C. (2013). SUVmax of 18FDG PET/CT as a predictor of high-risk endometrial cancer patients. Gynecologic Oncology, 129(2), 298-303. https://doi.org/10.1016/j.ygyno.2013.01.019

@article{1d64975fd03744b7a48c3e6edbbbcf2c,

title = "SUVmax of 18FDG PET/CT as a predictor of high-risk endometrial cancer patients",

abstract = "Objective: To evaluate SUVmax in the assessment of endometrial cancer preoperatively with particular focus on myometrial invasion (MI), cervical invasion (CI), FIGO stage, risk-stratification and lymph node metastases (LNM). Methods: A total of 268 women with endometrial cancer or atypical endometrial hyperplasia underwent FDG PET/CT imaging before surgical treatment. SUVmax of the primary tumour was compared with histological prognostic factors. Results: SUVmax was significantly higher in patients with high FIGO stages (p < 0.0001), deep MI (p = 0.002), CI (p = 0.04), LNM (p = 0.04) and high risk tumours (p = 0.003). Linear regression found that SUVmax was dependent of MI (p = 0.001, 95% CI 2.863-11.098), CI (p = 0.001, 95% CI 2.896-11.499), risk (p = 0.004, 95% CI 0.077-0.397), LNM (p = 0.04, 95% CI 0.011-0.482) and FIGO stage (p < 0.0001, 95% CI 0.158-0.473). Conclusions: Preoperative PET/CT scanning and SUVmax measurements of the primary tumour may provide additional clinical and prognostic information about MI, CI, LNM and high risk disease in patients with endometrial cancer and allow for individualization of patient care. However, the sensitivity and specificity of the SUVmax in staging endometrial cancer is not high enough to reliably replace surgical staging.",

author = "Antonsen, {Sofie Leisby} and Annika Loft and Fisker, {Rune Vincents} and Nielsen, {Anne Lerberg} and Andersen, {Erik S{\o}gaard} and Estrid H{\o}gdall and Ann Tabor and Jochumsen, {Kirsten V{\ae}ver} and Fag{\"o}-Olsen, {Carsten L} and Jon Asmussen and Berthelsen, {Anne Kiil} and Christensen, {Ib Jarle} and Claus H{\o}gdall",

year = "2013",

month = may,

doi = "10.1016/j.ygyno.2013.01.019",

language = "English",

volume = "129",

pages = "298--303",

journal = "Gynecologic Oncology",

issn = "0090-8258",

publisher = "Academic Press",

number = "2",

}

TY - JOUR

T1 - SUVmax of 18FDG PET/CT as a predictor of high-risk endometrial cancer patients

AU - Antonsen, Sofie Leisby

AU - Loft, Annika

AU - Fisker, Rune Vincents

AU - Nielsen, Anne Lerberg

AU - Andersen, Erik Søgaard

AU - Høgdall, Estrid

AU - Tabor, Ann

AU - Jochumsen, Kirsten Væver

AU - Fagö-Olsen, Carsten L

AU - Asmussen, Jon

AU - Berthelsen, Anne Kiil

AU - Christensen, Ib Jarle

AU - Høgdall, Claus

PY - 2013/5

Y1 - 2013/5

N2 - Objective: To evaluate SUVmax in the assessment of endometrial cancer preoperatively with particular focus on myometrial invasion (MI), cervical invasion (CI), FIGO stage, risk-stratification and lymph node metastases (LNM). Methods: A total of 268 women with endometrial cancer or atypical endometrial hyperplasia underwent FDG PET/CT imaging before surgical treatment. SUVmax of the primary tumour was compared with histological prognostic factors. Results: SUVmax was significantly higher in patients with high FIGO stages (p < 0.0001), deep MI (p = 0.002), CI (p = 0.04), LNM (p = 0.04) and high risk tumours (p = 0.003). Linear regression found that SUVmax was dependent of MI (p = 0.001, 95% CI 2.863-11.098), CI (p = 0.001, 95% CI 2.896-11.499), risk (p = 0.004, 95% CI 0.077-0.397), LNM (p = 0.04, 95% CI 0.011-0.482) and FIGO stage (p < 0.0001, 95% CI 0.158-0.473). Conclusions: Preoperative PET/CT scanning and SUVmax measurements of the primary tumour may provide additional clinical and prognostic information about MI, CI, LNM and high risk disease in patients with endometrial cancer and allow for individualization of patient care. However, the sensitivity and specificity of the SUVmax in staging endometrial cancer is not high enough to reliably replace surgical staging.

AB - Objective: To evaluate SUVmax in the assessment of endometrial cancer preoperatively with particular focus on myometrial invasion (MI), cervical invasion (CI), FIGO stage, risk-stratification and lymph node metastases (LNM). Methods: A total of 268 women with endometrial cancer or atypical endometrial hyperplasia underwent FDG PET/CT imaging before surgical treatment. SUVmax of the primary tumour was compared with histological prognostic factors. Results: SUVmax was significantly higher in patients with high FIGO stages (p < 0.0001), deep MI (p = 0.002), CI (p = 0.04), LNM (p = 0.04) and high risk tumours (p = 0.003). Linear regression found that SUVmax was dependent of MI (p = 0.001, 95% CI 2.863-11.098), CI (p = 0.001, 95% CI 2.896-11.499), risk (p = 0.004, 95% CI 0.077-0.397), LNM (p = 0.04, 95% CI 0.011-0.482) and FIGO stage (p < 0.0001, 95% CI 0.158-0.473). Conclusions: Preoperative PET/CT scanning and SUVmax measurements of the primary tumour may provide additional clinical and prognostic information about MI, CI, LNM and high risk disease in patients with endometrial cancer and allow for individualization of patient care. However, the sensitivity and specificity of the SUVmax in staging endometrial cancer is not high enough to reliably replace surgical staging.

U2 - 10.1016/j.ygyno.2013.01.019

DO - 10.1016/j.ygyno.2013.01.019

M3 - Journal article

SN - 0090-8258

VL - 129

SP - 298

EP - 303

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 2

ER -

SUVmax of 18FDG PET/CT as a predictor of high-risk endometrial cancer patients

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