Survival of selected patients with ovarian cancer treated with fertility-sparing surgery

TY - JOUR

T1 - Survival of selected patients with ovarian cancer treated with fertility-sparing surgery

AU - Hedbäck, Nora Elisabeth

AU - Karlsen, Mona Aarenstrup

AU - Høgdall, Claus Kim

AU - Rosendahl, Mikkel

N1 - Copyright © 2018. Published by Elsevier Ltd.

PY - 2018/7

Y1 - 2018/7

N2 - Research question: How many patients in Denmark were treated with fertility-sparing surgery (FSS) for epithelial ovarian cancer (EOC) and what was their prognosis compared with patients treated with radical surgery (RS)? Design: This study was a retrospective Danish nationwide study, evaluating the effect of FSS compared with RS in patients with EOC, age ≤45 years and International Federation of Gynecology and Obstetrics (FIGO) stage ≤IC3 from 2005 to 2016. Results: A total of 106 patients were included. Of these, 13 were treated with FSS and 93 were treated with RS. Median age was 27 versus 42 years (P < 0.0001). Overall survival did not differ significantly between the two groups. Overall survival rate in the FSS group was 100%, while the overall survival in the RS group was 87%. Disease-specific survival was 100% in the FSS group and 91% in the RS group. Conclusions: This study shows that patients treated with FSS for FIGO stage I EOC do not have an impaired survival compared with patients treated with RS. Nevertheless, the conclusion must be interpreted with caution due to the limited number of patients and the retrospective nature of the study. Larger studies are needed before conclusions can be drawn.

AB - Research question: How many patients in Denmark were treated with fertility-sparing surgery (FSS) for epithelial ovarian cancer (EOC) and what was their prognosis compared with patients treated with radical surgery (RS)? Design: This study was a retrospective Danish nationwide study, evaluating the effect of FSS compared with RS in patients with EOC, age ≤45 years and International Federation of Gynecology and Obstetrics (FIGO) stage ≤IC3 from 2005 to 2016. Results: A total of 106 patients were included. Of these, 13 were treated with FSS and 93 were treated with RS. Median age was 27 versus 42 years (P < 0.0001). Overall survival did not differ significantly between the two groups. Overall survival rate in the FSS group was 100%, while the overall survival in the RS group was 87%. Disease-specific survival was 100% in the FSS group and 91% in the RS group. Conclusions: This study shows that patients treated with FSS for FIGO stage I EOC do not have an impaired survival compared with patients treated with RS. Nevertheless, the conclusion must be interpreted with caution due to the limited number of patients and the retrospective nature of the study. Larger studies are needed before conclusions can be drawn.

KW - Adolescent

KW - Adult

KW - Denmark

KW - Disease-Free Survival

KW - Female

KW - Fertility Preservation/methods

KW - Humans

KW - Middle Aged

KW - Neoplasms, Glandular and Epithelial/mortality

KW - Organ Sparing Treatments/methods

KW - Ovarian Neoplasms/mortality

KW - Prognosis

KW - Retrospective Studies

KW - Survival Rate

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1016/j.rbmo.2018.03.018

DO - 10.1016/j.rbmo.2018.03.018

M3 - Journal article

C2 - 29685481

SN - 1472-6483

VL - 37

SP - 71

EP - 76

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

IS - 1

ER -