@article{38bd4edfcd4a45a1807827e4761d9eb7,
title = "Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways",
abstract = "The proinflammatory cytokine IL-1beta induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-kappaB (NF-kappaB), mitogen-activated protein kinase, and protein kinase C. We recently showed suppressor of cytokine signalling (SOCS)-3 to be a natural negative feedback regulator of IL-1beta- and IFN-gamma-mediated signalling in rat islets and beta cell lines, preventing their deleterious effects. However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown.",
keywords = "Animals, Apoptosis, Base Sequence, Cell Line, DNA Primers, Gene Expression Regulation, Interleukin-1, NF-kappa B, Nitric Oxide, Oligonucleotide Array Sequence Analysis, Rats, Repressor Proteins, Signal Transduction, Suppressor of Cytokine Signaling Proteins, Transcription Factors",
author = "Karlsen, {Allan Ertman} and Heding, {P E} and H Frob{\o}se and R{\o}nn, {S G} and M Kruh{\o}ffer and Orntoft, {T F} and M Darville and Eizirik, {D L} and F Pociot and J Nerup and Thomas Mandrup-Poulsen and N Billestrup",
year = "2004",
month = nov,
day = "1",
doi = "10.1007/s00125-004-1568-3",
language = "English",
volume = "47",
pages = "1998--2011",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "11",
}