Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease

TY - JOUR

T1 - Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease

AU - Dalgård, Christine

AU - Nielsen, Flemming Steen

AU - Morrow, Jason D

AU - Enghusen-Poulsen, Henrik

AU - Jonung, Torbjörn

AU - Hørder, Mogens

AU - de Maat, Moniek P M

N1 - Keywords: Antioxidants; Beverages; Biological Markers; C-Reactive Protein; Citrus sinensis; Dietary Supplements; Female; Fibrinogen; Humans; Interleukin-6; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Peripheral Vascular Diseases; Ribes; Statistics, Nonparametric; Vitamin E; von Willebrand Factor

PY - 2009

Y1 - 2009

N2 - Inflammation and endothelial activation are associated with an increased risk of CVD and epidemiological evidence suggests an association between levels of markers of inflammation or endothelial activation and the intake of fruit. Also, vitamin E, a fat-soluble antioxidant, has anti-inflammatory properties. We performed a randomised 2 x 2 factorial, crossover trial to determine the effect of orange and blackcurrant juice (500 ml/d) and vitamin E (15 mg RRR-alpha-tocopherol/d) supplementation on markers of inflammation and endothelial activation in forty-eight patients with peripheral arterial disease. Patients were randomly allocated to two dietary supplements from the four possible combinations of juice and vitamin E: juice+vitamin E; juice+placebo; reference beverage (sugar drink)+vitamin E; and reference beverage+placebo. The supplementations were given for 28 d, separated by a 4-week wash-out period. Analysis of main effects showed that juice decreased C-reactive protein (CRP) by 11% and fibrinogen by 3% while the reference drink increased CRP by 13% and fibrinogen by 2% (P

AB - Inflammation and endothelial activation are associated with an increased risk of CVD and epidemiological evidence suggests an association between levels of markers of inflammation or endothelial activation and the intake of fruit. Also, vitamin E, a fat-soluble antioxidant, has anti-inflammatory properties. We performed a randomised 2 x 2 factorial, crossover trial to determine the effect of orange and blackcurrant juice (500 ml/d) and vitamin E (15 mg RRR-alpha-tocopherol/d) supplementation on markers of inflammation and endothelial activation in forty-eight patients with peripheral arterial disease. Patients were randomly allocated to two dietary supplements from the four possible combinations of juice and vitamin E: juice+vitamin E; juice+placebo; reference beverage (sugar drink)+vitamin E; and reference beverage+placebo. The supplementations were given for 28 d, separated by a 4-week wash-out period. Analysis of main effects showed that juice decreased C-reactive protein (CRP) by 11% and fibrinogen by 3% while the reference drink increased CRP by 13% and fibrinogen by 2% (P

U2 - 10.1017/S0007114508995660

DO - 10.1017/S0007114508995660

M3 - Journal article

C2 - 18507878

SN - 0007-1145

VL - 101

SP - 263

EP - 269

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 2

ER -