suPAR: A New Biomarker for Cardiovascular Disease?

TY - JOUR

T1 - suPAR

T2 - A New Biomarker for Cardiovascular Disease?

AU - Hodges, Gethin W

AU - Bang, Casper N

AU - Wachtell, Kristian

AU - Eugen-Olsen, Jesper

AU - Jeppesen, Jørgen L

N1 - Copyright © 2015 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events and outperforms traditional markers of inflammation such as C-reactive protein (CRP) in prognosticating a range of CVDs. Furthermore, of particular interest is the suggestion that suPAR reflects a pathophysiological pathway more closely linked with subclinical organ damage than CRP. We provide the first comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events.

AB - The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events and outperforms traditional markers of inflammation such as C-reactive protein (CRP) in prognosticating a range of CVDs. Furthermore, of particular interest is the suggestion that suPAR reflects a pathophysiological pathway more closely linked with subclinical organ damage than CRP. We provide the first comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events.

KW - Biomarkers

KW - Cardiovascular Diseases

KW - Humans

KW - Inflammation

KW - Predictive Value of Tests

KW - Prognosis

KW - Receptors, Urokinase Plasminogen Activator

U2 - 10.1016/j.cjca.2015.03.023

DO - 10.1016/j.cjca.2015.03.023

M3 - Review

C2 - 26118447

SN - 0828-282X

VL - 31

SP - 1293

EP - 1302

JO - Canadian Journal of Cardiology

JF - Canadian Journal of Cardiology

IS - 10

ER -