Suicidal genetic elements and their use in biological containment of bacteria

Søren Molin; Lars Boe; L B Jensen; C S Kristensen; M Givskov; J L Ramos; A K Bej

doi:10.1146/annurev.mi.47.100193.001035

Suicidal genetic elements and their use in biological containment of bacteria

Søren Molin, Lars Boe, L B Jensen, C S Kristensen, M Givskov, J L Ramos, A K Bej

97 Citationer (Scopus)

Abstract

The potential risks of unintentional releases of genetically modified organisms, and the lack of predictable behavior of these in the environment, are the subject of considerable concern. This concern is accentuated in connection with the next phase of gene technology comprising deliberate releases. The possibilities of reducing such potential risks and increasing the predictability of the organisms are discussed for genetically engineered bacteria. Different approaches towards designing disabled strains without seriously reducing their beneficial effects are presented. Principally two types of strain design are discussed: actively contained bacteria based on the introduction of controlled suicide systems, and passively contained strains based on genetic interference with their survival under environmental-stress conditions.

Originalsprog	Engelsk
Tidsskrift	Annual Review of Microbiology
Vol/bind	47
Sider (fra-til)	139-66
Antal sider	28
ISSN	0066-4227
DOI	https://doi.org/10.1146/annurev.mi.47.100193.001035
Status	Udgivet - 1993
Udgivet eksternt	Ja

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10.1146/annurev.mi.47.100193.001035

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abstract = "The potential risks of unintentional releases of genetically modified organisms, and the lack of predictable behavior of these in the environment, are the subject of considerable concern. This concern is accentuated in connection with the next phase of gene technology comprising deliberate releases. The possibilities of reducing such potential risks and increasing the predictability of the organisms are discussed for genetically engineered bacteria. Different approaches towards designing disabled strains without seriously reducing their beneficial effects are presented. Principally two types of strain design are discussed: actively contained bacteria based on the introduction of controlled suicide systems, and passively contained strains based on genetic interference with their survival under environmental-stress conditions.",

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year = "1993",

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language = "English",

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T1 - Suicidal genetic elements and their use in biological containment of bacteria

AU - Molin, Søren

AU - Boe, Lars

AU - Jensen, L B

AU - Kristensen, C S

AU - Givskov, M

AU - Ramos, J L

AU - Bej, A K

PY - 1993

Y1 - 1993

N2 - The potential risks of unintentional releases of genetically modified organisms, and the lack of predictable behavior of these in the environment, are the subject of considerable concern. This concern is accentuated in connection with the next phase of gene technology comprising deliberate releases. The possibilities of reducing such potential risks and increasing the predictability of the organisms are discussed for genetically engineered bacteria. Different approaches towards designing disabled strains without seriously reducing their beneficial effects are presented. Principally two types of strain design are discussed: actively contained bacteria based on the introduction of controlled suicide systems, and passively contained strains based on genetic interference with their survival under environmental-stress conditions.

AB - The potential risks of unintentional releases of genetically modified organisms, and the lack of predictable behavior of these in the environment, are the subject of considerable concern. This concern is accentuated in connection with the next phase of gene technology comprising deliberate releases. The possibilities of reducing such potential risks and increasing the predictability of the organisms are discussed for genetically engineered bacteria. Different approaches towards designing disabled strains without seriously reducing their beneficial effects are presented. Principally two types of strain design are discussed: actively contained bacteria based on the introduction of controlled suicide systems, and passively contained strains based on genetic interference with their survival under environmental-stress conditions.

U2 - 10.1146/annurev.mi.47.100193.001035

DO - 10.1146/annurev.mi.47.100193.001035

M3 - Journal article

C2 - 8257096

SN - 0066-4227

VL - 47

SP - 139

EP - 166

JO - Annual Review of Microbiology

JF - Annual Review of Microbiology

ER -

Suicidal genetic elements and their use in biological containment of bacteria

Abstract

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