Successful Treatment of Rhino-Orbital-Cerebral Mucormycosis in a Child with Leukemia

Thorbjørn S.R. Jensen; Maiken C. Arendrup; Christian Von Buchvald; Thomas L. Frandsen; Marianne Juhler; Ulrikka Nygaard

doi:10.1097/MPH.0000000000000701

Successful Treatment of Rhino-Orbital-Cerebral Mucormycosis in a Child with Leukemia

Thorbjørn S.R. Jensen^*, Maiken C. Arendrup, Christian Von Buchvald, Thomas L. Frandsen, Marianne Juhler, Ulrikka Nygaard

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

7 Citationer (Scopus)

Abstract

Rhino-orbital-cerebral mucormycosis (ROCM) is a rare fulminant opportunistic fungal infection that despite relevant treatment has high mortality. We present a case of a 3-year-old girl with acute lymphoblastic leukemia and ROCM, who was treated successfully with excessive surgery, systemic antifungal treatment with amphotericin B (AmB), posaconazole, and terbinafine as well as hyperbaric oxygen. Surgery included, beside extracranial and intracranial removal of infected areas, endoscopic sinus and skull base surgery with local AmB installation and in addition placement of an Ommaya reservoir for 114 intrathecal administrations of AmB. In addition, we review the literature of ROCM in pediatric patients with hematological diseases.

Originalsprog	Engelsk
Tidsskrift	Journal of Pediatric Hematology/Oncology
Vol/bind	39
Udgave nummer	4
Sider (fra-til)	e211-e215
ISSN	1077-4114
DOI	https://doi.org/10.1097/MPH.0000000000000701
Status	Udgivet - maj 2017

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10.1097/MPH.0000000000000701

Citationsformater

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title = "Successful Treatment of Rhino-Orbital-Cerebral Mucormycosis in a Child with Leukemia",

abstract = "Rhino-orbital-cerebral mucormycosis (ROCM) is a rare fulminant opportunistic fungal infection that despite relevant treatment has high mortality. We present a case of a 3-year-old girl with acute lymphoblastic leukemia and ROCM, who was treated successfully with excessive surgery, systemic antifungal treatment with amphotericin B (AmB), posaconazole, and terbinafine as well as hyperbaric oxygen. Surgery included, beside extracranial and intracranial removal of infected areas, endoscopic sinus and skull base surgery with local AmB installation and in addition placement of an Ommaya reservoir for 114 intrathecal administrations of AmB. In addition, we review the literature of ROCM in pediatric patients with hematological diseases.",

keywords = "acute lymphoblastic leukemia, excessive surgery, Ommaya reservoir, pediatric, rhino-orbital-cerebral mucormycosis, survival",

author = "Jensen, {Thorbj{\o}rn S.R.} and Arendrup, {Maiken C.} and {Von Buchvald}, Christian and Frandsen, {Thomas L.} and Marianne Juhler and Ulrikka Nygaard",

year = "2017",

month = may,

doi = "10.1097/MPH.0000000000000701",

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pages = "e211--e215",

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T1 - Successful Treatment of Rhino-Orbital-Cerebral Mucormycosis in a Child with Leukemia

AU - Jensen, Thorbjørn S.R.

AU - Arendrup, Maiken C.

AU - Von Buchvald, Christian

AU - Frandsen, Thomas L.

AU - Juhler, Marianne

AU - Nygaard, Ulrikka

PY - 2017/5

Y1 - 2017/5

N2 - Rhino-orbital-cerebral mucormycosis (ROCM) is a rare fulminant opportunistic fungal infection that despite relevant treatment has high mortality. We present a case of a 3-year-old girl with acute lymphoblastic leukemia and ROCM, who was treated successfully with excessive surgery, systemic antifungal treatment with amphotericin B (AmB), posaconazole, and terbinafine as well as hyperbaric oxygen. Surgery included, beside extracranial and intracranial removal of infected areas, endoscopic sinus and skull base surgery with local AmB installation and in addition placement of an Ommaya reservoir for 114 intrathecal administrations of AmB. In addition, we review the literature of ROCM in pediatric patients with hematological diseases.

AB - Rhino-orbital-cerebral mucormycosis (ROCM) is a rare fulminant opportunistic fungal infection that despite relevant treatment has high mortality. We present a case of a 3-year-old girl with acute lymphoblastic leukemia and ROCM, who was treated successfully with excessive surgery, systemic antifungal treatment with amphotericin B (AmB), posaconazole, and terbinafine as well as hyperbaric oxygen. Surgery included, beside extracranial and intracranial removal of infected areas, endoscopic sinus and skull base surgery with local AmB installation and in addition placement of an Ommaya reservoir for 114 intrathecal administrations of AmB. In addition, we review the literature of ROCM in pediatric patients with hematological diseases.

KW - acute lymphoblastic leukemia

KW - excessive surgery

KW - Ommaya reservoir

KW - pediatric

KW - rhino-orbital-cerebral mucormycosis

KW - survival

U2 - 10.1097/MPH.0000000000000701

DO - 10.1097/MPH.0000000000000701

M3 - Journal article

C2 - 27841827

AN - SCOPUS:84995486955

SN - 1077-4114

VL - 39

SP - e211-e215

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

IS - 4

ER -

Successful Treatment of Rhino-Orbital-Cerebral Mucormycosis in a Child with Leukemia

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