@article{6c05bd90328c11df8ed1000ea68e967b,
title = "Successful nonsibling bone marrow transplantation in severe combined immunodeficiency",
abstract = "Severe combined immunodeficiency (SCID) was diagnosed in a girl immediately after birth; her older brother had SCID and was successfully reconstituted by bone marrow transplantation from his uncle. She was isolated in a laminar air flow bench and decontaminated. The father differed by one HLA-A antigen but was HLA-Dw2 homozygous like the patient; his lymphocytes showed a slight response to the patient's cells in mixed lymphocyte culture (MLC). At the age of 2 1/2 months and again at 5 months, she was given a bone marrow transplant from the father. During the entire course the patient had no infections, and apart from a transient eosinophilia she had no signs of graft-versus-host reaction. Immunological reconstitution was nearly complete at 9 months of age, when she was recontaminated. One year later plasma immunoglobulin concentrations are in the low normal range (IgG and IgM) or decreased (IgA); tests of cell-mediated immunity are normal. Apart from slight upper respiratory infections, the patient has been healthy. Physical and psychological development have been normal.",
author = "K Rams{\o}e and P Skinh{\o}j and V Andersen and P Ernst and V Faber and P Platz and M Thomsen and A Svejgaard and Eriksen, {K R} and T Plesner and N Morling and J Philip and Killmann, {S A} and C Koch and N Muller-B{\'e}rat and K Henningsen and H Axelsen",
note = "Keywords: Bone Marrow Transplantation; Female; HLA Antigens; Humans; Immunologic Deficiency Syndromes; Infant; Male; Pedigree; Transplantation, Homologous",
year = "1978",
language = "English",
volume = "26",
pages = "369--72",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams & Wilkins",
number = "6",
}