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Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme
Andreas Stahl Madsen,
Christian Adam Olsen
41
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Keyphrases
Deacylase
100%
NAD-dependent
100%
Lysine
100%
Fluorometric
100%
Sirtuins
75%
Chemotype
25%
Drug Target
25%
Commercially Available
25%
Substrate Pocket
25%
Suramin
25%
Enzyme Kinetics
25%
Protocol Optimization
25%
Kinetic Analysis
25%
Screening Protocol
25%
Therapeutic Intervention
25%
Fluorogenic Substrate
25%
Mechanistic Insight
25%
X-ray Crystallography
25%
Isozymes
25%
High Efficiency
25%
Hydrolases
25%
Biochemistry, Genetics and Molecular Biology
Lysine
100%
Enzyme
100%
Sirtuin
100%
X-Ray Crystallography
12%
Hydrolase
12%
Isoenzyme
12%
Enzyme Kinetics
12%
Small Molecule
12%
Posttranslational Modification
12%
Kinetics
12%
Suramin
12%
Chemistry
Suramin
33%