Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype

TY - JOUR

T1 - Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype

AU - Kragelund, Camilla

AU - Jensen, Siri Beier

AU - Hansen, Claus

AU - Brosen, K.

AU - Torpet, Lis Andersen

AU - Reibel, Jesper

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objective This study aimed to determine if the activity of the environmentally influenced cytochrome P450 enzyme CYP1A2, alone or in combination with CYP2D6∗4 genotype, discriminates subgroups of oral lichen planus (OLP) according to lifestyle factors and clinical manifestations. Study Design A total of 111 patients with OLP were categorized according to normal, low, or high CYP1A2 activity and CYP2D6∗4 genotype. Lifestyle parameters influencing the CYP1A2 activity and symptoms and manifestations of OLP were recorded. Results Of the 111 patients, 21% had low, 65% normal, and 14% high CYP1A2 activity. The high-CYP1A2-activity group was more exposed to CYP1A2 inducers than the low-CYP1A2-activity group. In the normal-CYP1A2-activity group, more patients had a CYP2D6∗4 genotype (58%) (P =.02), and they presented more symptoms (P =.003) and gingival lesions (P =.03). More patients in the low-CYP1A2-activity group and without CYP2D6∗4 genotype presented red lesions (P =.04). Conclusions We suggest CYP2D6∗4 genotype as a disease-susceptible genotype and low or high CYP1A2 activity levels as indicators of environmental influence in OLP subgroups.

AB - Objective This study aimed to determine if the activity of the environmentally influenced cytochrome P450 enzyme CYP1A2, alone or in combination with CYP2D6∗4 genotype, discriminates subgroups of oral lichen planus (OLP) according to lifestyle factors and clinical manifestations. Study Design A total of 111 patients with OLP were categorized according to normal, low, or high CYP1A2 activity and CYP2D6∗4 genotype. Lifestyle parameters influencing the CYP1A2 activity and symptoms and manifestations of OLP were recorded. Results Of the 111 patients, 21% had low, 65% normal, and 14% high CYP1A2 activity. The high-CYP1A2-activity group was more exposed to CYP1A2 inducers than the low-CYP1A2-activity group. In the normal-CYP1A2-activity group, more patients had a CYP2D6∗4 genotype (58%) (P =.02), and they presented more symptoms (P =.003) and gingival lesions (P =.03). More patients in the low-CYP1A2-activity group and without CYP2D6∗4 genotype presented red lesions (P =.04). Conclusions We suggest CYP2D6∗4 genotype as a disease-susceptible genotype and low or high CYP1A2 activity levels as indicators of environmental influence in OLP subgroups.

U2 - 10.1016/j.oooo.2014.06.008

DO - 10.1016/j.oooo.2014.06.008

M3 - Journal article

C2 - 25240994

SN - 1079-2104

VL - 118

SP - 469

EP - 474

JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

IS - 4

M1 - 951

ER -