Study of the complexation of oxacillin in 1-(4-Carbomethoxypyrrolidone)-terminated PAMAM dendrimers

Jon Stefan Hansen; Mario Ficker; Johannes Fabritius Petersen; Bjarne Enrico Nielsen; Saira Gohar; Jørn Bolstad Christensen

doi:10.1021/jp408613z

Study of the complexation of oxacillin in 1-(4-Carbomethoxypyrrolidone)-terminated PAMAM dendrimers

Jon Stefan Hansen, Mario Ficker, Johannes Fabritius Petersen, Bjarne Enrico Nielsen, Saira Gohar, Jørn Bolstad Christensen

Kemisk Institut

5 Citationer (Scopus)

Abstract

The complexation of oxacillin to three generations of 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied with NMR in CD3OD and CDCl3. The stochiometries, which were determined from Job plots, were found to be both solvent- and generation-dependent. The dissociation constants (Kd) and Gibbs energies for complexation of oxacillin into the 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimer hosts were determined by (1)H NMR titrations and showed weaker binding of oxacillin upon increasing the size (generation) of the dendrimer.

Originalsprog	Engelsk
Tidsskrift	Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical
Vol/bind	117
Udgave nummer	47
Sider (fra-til)	14865-14874
Antal sider	10
ISSN	1520-6106
DOI	https://doi.org/10.1021/jp408613z
Status	Udgivet - 27 nov. 2013

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10.1021/jp408613z

Citationsformater

Study of the complexation of oxacillin in 1-(4-Carbomethoxypyrrolidone)-terminated PAMAM dendrimers. / Hansen, Jon Stefan; Ficker, Mario; Petersen, Johannes Fabritius et al.

I: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, Bind 117, Nr. 47, 27.11.2013, s. 14865-14874.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Study of the complexation of oxacillin in 1-(4-Carbomethoxypyrrolidone)-terminated PAMAM dendrimers",

abstract = "The complexation of oxacillin to three generations of 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied with NMR in CD3OD and CDCl3. The stochiometries, which were determined from Job plots, were found to be both solvent- and generation-dependent. The dissociation constants (Kd) and Gibbs energies for complexation of oxacillin into the 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimer hosts were determined by (1)H NMR titrations and showed weaker binding of oxacillin upon increasing the size (generation) of the dendrimer.",

author = "Hansen, {Jon Stefan} and Mario Ficker and Petersen, {Johannes Fabritius} and Nielsen, {Bjarne Enrico} and Saira Gohar and Christensen, {J{\o}rn Bolstad}",

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AU - Hansen, Jon Stefan

AU - Ficker, Mario

AU - Petersen, Johannes Fabritius

AU - Nielsen, Bjarne Enrico

AU - Gohar, Saira

AU - Christensen, Jørn Bolstad

PY - 2013/11/27

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N2 - The complexation of oxacillin to three generations of 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied with NMR in CD3OD and CDCl3. The stochiometries, which were determined from Job plots, were found to be both solvent- and generation-dependent. The dissociation constants (Kd) and Gibbs energies for complexation of oxacillin into the 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimer hosts were determined by (1)H NMR titrations and showed weaker binding of oxacillin upon increasing the size (generation) of the dendrimer.

AB - The complexation of oxacillin to three generations of 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied with NMR in CD3OD and CDCl3. The stochiometries, which were determined from Job plots, were found to be both solvent- and generation-dependent. The dissociation constants (Kd) and Gibbs energies for complexation of oxacillin into the 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimer hosts were determined by (1)H NMR titrations and showed weaker binding of oxacillin upon increasing the size (generation) of the dendrimer.

U2 - 10.1021/jp408613z

DO - 10.1021/jp408613z

M3 - Journal article

C2 - 24219418

SN - 1520-6106

VL - 117

SP - 14865

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JO - Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical

JF - Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical

IS - 47

ER -

Study of the complexation of oxacillin in 1-(4-Carbomethoxypyrrolidone)-terminated PAMAM dendrimers

Abstract

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