Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

Kristoffer Sølvsten Burgdorf; Camilla Helene Sandholt; Thomas Sparsø; Gitte Andersen; Daniel R Witte; Torben Jørgensen; Anelli Sandbaek; Torsten Lauritzen; Thorkild I A Sørensen; Sten Madsbad; Torben Hansen; Oluf Pedersen

doi:10.1530/eje-10-0068

Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

Kristoffer Sølvsten Burgdorf, Camilla Helene Sandholt, Thomas Sparsø, Gitte Andersen, Daniel R Witte, Torben Jørgensen, Anelli Sandbaek, Torsten Lauritzen, Thorkild I A Sørensen, Sten Madsbad, Torben Hansen, Oluf Pedersen

10 Citationer (Scopus)

Abstract

Objective: Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population. Design: In the present study, variants were analyzed in LPIN1 using case - control studies, haplotype analyses, and quantitative trait analyses in a population of 17 538 Danes. Methods: The three LPIN1 variants were genotyped in 17 538 Danes from four study populations of middle-aged people. This provided us with a statistical power >99% to replicate previous findings. Variants were analyzed individually and in haplotype combinations in studies of quantitative metabolic traits and in case - control studies. Results: None of the three variants were associated with the examined quantitative traits including BMI, waist circumference, blood pressure, fasting serum lipid concentrations, or plasma glucose or serum insulin concentrations in the fasting state and following an oral glucose tolerance test. Haplotypes were tested for association with quantitative traits; however, only nominal association with blood pressure (P=0.04) and waist circumference (P=0.04) was observed. In case - control studies, no association was found for individual variants or the three-marker haplotype. Conclusion: LPIN1 rs33997857, rs6744682, and rs6708316 did not associate with type 2 diabetes, obesity, or related quantitative metabolic phenotypes in the Danish population examined.

Originalsprog	Engelsk
Tidsskrift	European Journal of Endocrinology
Vol/bind	163
Udgave nummer	1
Sider (fra-til)	81-7
Antal sider	7
ISSN	0804-4643
DOI	https://doi.org/10.1530/eje-10-0068
Status	Udgivet - 1 jul. 2010

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10.1530/eje-10-0068

https://eje.bioscientifica.com/downloadpdf/journals/eje/163/1/81.pdf

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Burgdorf, K. S., Sandholt, C. H., Sparsø, T., Andersen, G., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Sørensen, T. I. A., Madsbad, S., Hansen, T., & Pedersen, O. (2010). Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes. European Journal of Endocrinology, 163(1), 81-7. https://doi.org/10.1530/eje-10-0068

@article{f132763df2e3494cbbde52c8f28c6cc0,

title = "Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes",

abstract = "Objective: Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population. Design: In the present study, variants were analyzed in LPIN1 using case - control studies, haplotype analyses, and quantitative trait analyses in a population of 17 538 Danes. Methods: The three LPIN1 variants were genotyped in 17 538 Danes from four study populations of middle-aged people. This provided us with a statistical power >99% to replicate previous findings. Variants were analyzed individually and in haplotype combinations in studies of quantitative metabolic traits and in case - control studies. Results: None of the three variants were associated with the examined quantitative traits including BMI, waist circumference, blood pressure, fasting serum lipid concentrations, or plasma glucose or serum insulin concentrations in the fasting state and following an oral glucose tolerance test. Haplotypes were tested for association with quantitative traits; however, only nominal association with blood pressure (P=0.04) and waist circumference (P=0.04) was observed. In case - control studies, no association was found for individual variants or the three-marker haplotype. Conclusion: LPIN1 rs33997857, rs6744682, and rs6708316 did not associate with type 2 diabetes, obesity, or related quantitative metabolic phenotypes in the Danish population examined.",

keywords = "Adult, Body Mass Index, Case-Control Studies, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genetic Variation, Genotype, Haplotypes, Humans, Male, Middle Aged, Nuclear Proteins, Obesity, Waist Circumference",

author = "Burgdorf, {Kristoffer S{\o}lvsten} and Sandholt, {Camilla Helene} and Thomas Spars{\o} and Gitte Andersen and Witte, {Daniel R} and Torben J{\o}rgensen and Anelli Sandbaek and Torsten Lauritzen and S{\o}rensen, {Thorkild I A} and Sten Madsbad and Torben Hansen and Oluf Pedersen",

year = "2010",

month = jul,

day = "1",

doi = "10.1530/eje-10-0068",

language = "English",

volume = "163",

pages = "81--7",

journal = "European Journal of Endocrinology",

issn = "0804-4643",

publisher = "BioScientifica Ltd.",

number = "1",

}

TY - JOUR

T1 - Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

AU - Burgdorf, Kristoffer Sølvsten

AU - Sandholt, Camilla Helene

AU - Sparsø, Thomas

AU - Andersen, Gitte

AU - Witte, Daniel R

AU - Jørgensen, Torben

AU - Sandbaek, Anelli

AU - Lauritzen, Torsten

AU - Sørensen, Thorkild I A

AU - Madsbad, Sten

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Objective: Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population. Design: In the present study, variants were analyzed in LPIN1 using case - control studies, haplotype analyses, and quantitative trait analyses in a population of 17 538 Danes. Methods: The three LPIN1 variants were genotyped in 17 538 Danes from four study populations of middle-aged people. This provided us with a statistical power >99% to replicate previous findings. Variants were analyzed individually and in haplotype combinations in studies of quantitative metabolic traits and in case - control studies. Results: None of the three variants were associated with the examined quantitative traits including BMI, waist circumference, blood pressure, fasting serum lipid concentrations, or plasma glucose or serum insulin concentrations in the fasting state and following an oral glucose tolerance test. Haplotypes were tested for association with quantitative traits; however, only nominal association with blood pressure (P=0.04) and waist circumference (P=0.04) was observed. In case - control studies, no association was found for individual variants or the three-marker haplotype. Conclusion: LPIN1 rs33997857, rs6744682, and rs6708316 did not associate with type 2 diabetes, obesity, or related quantitative metabolic phenotypes in the Danish population examined.

AB - Objective: Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population. Design: In the present study, variants were analyzed in LPIN1 using case - control studies, haplotype analyses, and quantitative trait analyses in a population of 17 538 Danes. Methods: The three LPIN1 variants were genotyped in 17 538 Danes from four study populations of middle-aged people. This provided us with a statistical power >99% to replicate previous findings. Variants were analyzed individually and in haplotype combinations in studies of quantitative metabolic traits and in case - control studies. Results: None of the three variants were associated with the examined quantitative traits including BMI, waist circumference, blood pressure, fasting serum lipid concentrations, or plasma glucose or serum insulin concentrations in the fasting state and following an oral glucose tolerance test. Haplotypes were tested for association with quantitative traits; however, only nominal association with blood pressure (P=0.04) and waist circumference (P=0.04) was observed. In case - control studies, no association was found for individual variants or the three-marker haplotype. Conclusion: LPIN1 rs33997857, rs6744682, and rs6708316 did not associate with type 2 diabetes, obesity, or related quantitative metabolic phenotypes in the Danish population examined.

KW - Adult

KW - Body Mass Index

KW - Case-Control Studies

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Male

KW - Middle Aged

KW - Nuclear Proteins

KW - Obesity

KW - Waist Circumference

U2 - 10.1530/eje-10-0068

DO - 10.1530/eje-10-0068

M3 - Journal article

C2 - 20356931

SN - 0804-4643

VL - 163

SP - 81

EP - 87

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 1

ER -

Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

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