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Structure–Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors
Xiaofeng Xiong,
Mette H Poulsen
, Rama A Hussein, Niels G Nørager,
Kristian Strømgaard
5
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Alfabetisk
Medicin og biovidenskab
Spiders
100%
Ionotropic Glutamate Receptors
98%
Polyamines
86%
JSTX spider toxin
47%
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
30%
Venoms
29%
AMPA Receptors
28%
Structure-Activity Relationship
28%
N-Methylaspartate
26%
Biological Products
24%
Head
17%
Pharmacology
16%
2-(2-(1H-indol-3-yl)acetamido)-N1-(5-(3-(4-(3-aminopropylamino)butylamino)propanamido)pentyl)succinamide
3%
N1-(5-(3-(4-(3-aminopropylamino)butylamino)propanamido)pentyl)-2-(2-(4-hydroxy-1H-indol-3-yl)acetamido)succinamide
3%
Kemiske forbindelser
Polyamine
78%
Toxin
70%
Venom
28%
Structure-Activity Relationship
20%
Occurrence in Nature
20%
Bioactivity
17%