@article{433ef7c0540611dd8d9f000ea68e967b,
title = "Structure of mink immunoglobulin gamma chain cDNA.",
abstract = "Two cDNA clones, encoding mink Ig gamma chains were characterized. The pIGG47 clone contains a part of the leader segment, VDJ and C regions, and pIGG14 contains a part of the J and a complete C region. The clones differ by only four nucleotides in the C region, and they most probably represent allelic variants of the same gene. The V gene segment of pIGG47 was found to be highly similar to human VHIII subgroup sequences; there was 86-87% similarity for the whole V gene segment and 91% for the VHIII specific regions (codons 65-87). Southern blot analysis demonstrated that a high proportion of mink VH genes is VHIII related. The V gene segment used as a probe revealed 19-23 bands in mink DNA under stringent conditions. This is in agreement with our previous data showing that a high proportion of mink Ig contains an 'alternative' binding site for protein A, a feature common to VHIII-related molecules. According to Southern blot analysis there may be 5-7 C gamma genes at the mink IgH locus.",
author = "Najakshin, {A M} and Belousov, {E S} and {Alabyev BYu} and Christensen, {Jesper Aagaard} and T Storgaard and B Aasted and Taranin, {A V}",
note = "Keywords: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA, Complementary; Genes, Immunoglobulin; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Immunoglobulin gamma-Chains; Mice; Mink; Molecular Sequence Data; Rabbits; Spleen",
year = "1997",
language = "English",
volume = "20",
pages = "231--40",
journal = "Developmental and Comparative Immunology",
issn = "0145-305X",
publisher = "Pergamon",
number = "4",
}