Stroke rehabilitation at home before and after discharge reduced disability and improved quality of life: a randomised controlled trial

TY - JOUR

T1 - Stroke rehabilitation at home before and after discharge reduced disability and improved quality of life

T2 - a randomised controlled trial

AU - Rasmussen, Rune Skovgaard

AU - Østergaard, Ann

AU - Kjær, Pia

AU - Skerris, Anja

AU - Skou, Christina T.

AU - Christoffersen, Jane

AU - Seest, Line Skou

AU - Poulsen, Mai Bang

AU - Rønholt, Finn

AU - Overgaard, Karsten

N1 - © The Author(s) 2015.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Objective: To evaluate if home-based rehabilitation of inpatients improved outcome compared to standard care. Design: Interventional, randomised, safety/efficacy open-label trial. Setting: University hospital stroke unit in collaboration with three municipalities. Subjects: Seventy-one eligible stroke patients (41 women) with focal neurological deficits hospitalised in a stroke unit for more than three days and in need of rehabilitation. Interventions: Thirty-eight patients were randomised to home-based rehabilitation during hospitalization and for up to four weeks after discharge to replace part of usual treatment and rehabilitation services. Thirty-three control patients received treatment and rehabilitation following usual guidelines for the treatment of stroke patients. Main measures: Ninety days post-stroke the modified Rankin Scale score was the primary endpoint. Other outcome measures were the modified Barthel-100 Index, Motor Assessment Scale, CT-50 Cognitive Test, EuroQol-5D™, Body Mass Index and treatment-associated economy. Results: Thirty-one intervention and 30 control patients completed the study. Patients in the intervention group achieved better modified Rankin Scale score (Intervention median = 2, IQR = 2-3; Control median = 3, IQR = 2-4; P=0.04). EuroQol-5D™ quality of life median scores were improved in intervention patients (Intervention median = 0.77, IQR = 0.66-0.79; Control median = 0.66, IQR = 0.56 - 0.72; P=0.03). The total amount of home-based training in minutes highly correlated with MRS, Barthel, Motor Assessment Scale and EuroQol-5D™ scores (P-values ranging from P<0.00001 to P=0.01). Economical estimations of intervention costs were lower than total costs of standard treatment. Conclusion: Early home-based rehabilitation reduced disability and increased quality of life. Compared to standard care, home-based stroke rehabilitation was more cost-effective.

AB - Objective: To evaluate if home-based rehabilitation of inpatients improved outcome compared to standard care. Design: Interventional, randomised, safety/efficacy open-label trial. Setting: University hospital stroke unit in collaboration with three municipalities. Subjects: Seventy-one eligible stroke patients (41 women) with focal neurological deficits hospitalised in a stroke unit for more than three days and in need of rehabilitation. Interventions: Thirty-eight patients were randomised to home-based rehabilitation during hospitalization and for up to four weeks after discharge to replace part of usual treatment and rehabilitation services. Thirty-three control patients received treatment and rehabilitation following usual guidelines for the treatment of stroke patients. Main measures: Ninety days post-stroke the modified Rankin Scale score was the primary endpoint. Other outcome measures were the modified Barthel-100 Index, Motor Assessment Scale, CT-50 Cognitive Test, EuroQol-5D™, Body Mass Index and treatment-associated economy. Results: Thirty-one intervention and 30 control patients completed the study. Patients in the intervention group achieved better modified Rankin Scale score (Intervention median = 2, IQR = 2-3; Control median = 3, IQR = 2-4; P=0.04). EuroQol-5D™ quality of life median scores were improved in intervention patients (Intervention median = 0.77, IQR = 0.66-0.79; Control median = 0.66, IQR = 0.56 - 0.72; P=0.03). The total amount of home-based training in minutes highly correlated with MRS, Barthel, Motor Assessment Scale and EuroQol-5D™ scores (P-values ranging from P<0.00001 to P=0.01). Economical estimations of intervention costs were lower than total costs of standard treatment. Conclusion: Early home-based rehabilitation reduced disability and increased quality of life. Compared to standard care, home-based stroke rehabilitation was more cost-effective.

U2 - 10.1177/0269215515575165

DO - 10.1177/0269215515575165

M3 - Journal article

C2 - 25758941

SN - 0269-2155

VL - 30

SP - 225

EP - 236

JO - Clinical Rehabilitation

JF - Clinical Rehabilitation

IS - 3

ER -