@article{8489e1576ef34b0db66717e50dabbc0a,
title = "Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter",
abstract = "Background: The serotonin transporter contains an allosteric binding site with unknown location. Results: We use molecular modeling, mutagenesis, and zinc site engineering to locate and inhibit the allosteric binding site. Conclusion: Data are consistent with the allosteric binding site being located in the extracellular vestibule. Significance: This opens the search for a new generation of antidepressant drugs directed toward the proposed allosteric binding site.",
keywords = "Allosteric Site, Antidepressive Agents, Second-Generation, Citalopram, Humans, Molecular Docking Simulation, Molecular Dynamics Simulation, Mutagenesis, Protein Structure, Tertiary, Serotonin Plasma Membrane Transport Proteins, Zinc",
author = "Per Plenge and Lei Shi and Thijs Beuming and Jerez Te and Newman, {Amy Hauck} and Harel Weinstein and Ulrik Gether and Loland, {Claus J}",
year = "2012",
month = nov,
day = "16",
doi = "10.1074/jbc.M112.371765",
language = "English",
volume = "287",
pages = "39316--26",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology, Inc.",
number = "47",
}