Staging of early lymph node metastases with the sentinel lymph node technique and predictive factors in T1/T2 oral cavity cancer: A retrospective single-center study

TY - JOUR

T1 - Staging of early lymph node metastases with the sentinel lymph node technique and predictive factors in T1/T2 oral cavity cancer

T2 - A retrospective single-center study

AU - Pedersen, Nicklas Juel

AU - Jensen, David Hebbelstrup

AU - Hedbäck, Nora

AU - Frendø, Martin

AU - Kiss, Katalin

AU - Lelkaitis, Giedrius

AU - Mortensen, Jann

AU - Christensen, Anders

AU - Specht, Lena

AU - von Buchwald, Christian

N1 - © 2015 Wiley Periodicals, Inc.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background The purpose of this study was to examine the diagnostic accuracy of detecting lymph node metastases and to identify predictive and prognostic clinicopathological factors in patients with oral squamous cell carcinoma (OSCC) undergoing sentinel lymph node biopsy (SLNB). Methods All patients diagnosed with cT1 to T2N0 OSCC who underwent a diagnostic SLNB between 2007 and 2013 were included. Results We identified 253 patients, of whom 27% had a positive sentinel lymph node (SLB). The false-negative rate, sensitivity, and negative predictive value (NPV) were 5%, 88%, and 95%, respectively. Patients with micrometastases as well as macrometastases had a separately, significantly shorter disease-specific survival than patients with pN0 disease. In a logistic regression model, the maximum tumor thickness, perineural invasion, and differentiation grade were independent predictive factors for the presence of metastases. Conclusion These data support the use of the SLNB technique as an accurate and safe staging tool in patients with OSCC with a cN0 neck.

AB - Background The purpose of this study was to examine the diagnostic accuracy of detecting lymph node metastases and to identify predictive and prognostic clinicopathological factors in patients with oral squamous cell carcinoma (OSCC) undergoing sentinel lymph node biopsy (SLNB). Methods All patients diagnosed with cT1 to T2N0 OSCC who underwent a diagnostic SLNB between 2007 and 2013 were included. Results We identified 253 patients, of whom 27% had a positive sentinel lymph node (SLB). The false-negative rate, sensitivity, and negative predictive value (NPV) were 5%, 88%, and 95%, respectively. Patients with micrometastases as well as macrometastases had a separately, significantly shorter disease-specific survival than patients with pN0 disease. In a logistic regression model, the maximum tumor thickness, perineural invasion, and differentiation grade were independent predictive factors for the presence of metastases. Conclusion These data support the use of the SLNB technique as an accurate and safe staging tool in patients with OSCC with a cN0 neck.

U2 - 10.1002/hed.24153

DO - 10.1002/hed.24153

M3 - Journal article

C2 - 26040238

SN - 1043-3074

VL - 38

SP - 1

EP - 8

JO - Head & Neck (Print Edition)

JF - Head & Neck (Print Edition)

IS - S1

ER -