Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort

Howards Penelope; Irva Hertz-Picciotto; Bodil Hammer Bech; Ellen Aagaard Nøhr; Anne-Marie Nybo Andersen; Charles Poole; Jørn Olsen

doi:10.1371/journal.pone.0050372

Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort

Howards Penelope, Irva Hertz-Picciotto, Bodil Hammer Bech, Ellen Aagaard Nøhr, Anne-Marie Nybo Andersen, Charles Poole, Jørn Olsen

https://www.ifsv.ku.dk/om-instituttet/socialmedicin/

7 Citationer (Scopus)

Abstract

Background: Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Danish National Birth Cohort. Methods: Women were recruited during their first prenatal visit from 1996-2002. Pre-conception and early pregnancy medication use was reported on the enrollment form, and pregnancy outcome was determined by linking the mother's Civil Registration Number to the Medical Birth Registry and the National Hospital Discharge Register. Of 97,903 eligible pregnancies, 4,443 ended in SAB between 5 and 20 completed gestational weeks, inclusive. Letigen use was reported for 565 pregnancies. Cox regression models accounting for left truncation were fit to estimate the effect of pre-conception and early pregnancy Letigen use on SAB. Principal Findings: The estimated maternal age-adjusted hazard ratio for SAB was 1.1 (95% confidence interval 0.8-1.6) for any periconceptional Letigen use compared to no periconceptional use. Conclusions: Although Letigen has high levels of caffeine (the recommended 3 pills/day are approximately equivalent to caffeine from 6 cups of coffee), periconceptional use does not appear to be associated with an appreciably increased hazard of clinically recognized SAB.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	11
Sider (fra-til)	e50372
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0050372
Status	Udgivet - 16 nov. 2012

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10.1371/journal.pone.0050372

Citationsformater

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title = "Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort",

abstract = "Background: Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Danish National Birth Cohort. Methods: Women were recruited during their first prenatal visit from 1996-2002. Pre-conception and early pregnancy medication use was reported on the enrollment form, and pregnancy outcome was determined by linking the mother's Civil Registration Number to the Medical Birth Registry and the National Hospital Discharge Register. Of 97,903 eligible pregnancies, 4,443 ended in SAB between 5 and 20 completed gestational weeks, inclusive. Letigen use was reported for 565 pregnancies. Cox regression models accounting for left truncation were fit to estimate the effect of pre-conception and early pregnancy Letigen use on SAB. Principal Findings: The estimated maternal age-adjusted hazard ratio for SAB was 1.1 (95% confidence interval 0.8-1.6) for any periconceptional Letigen use compared to no periconceptional use. Conclusions: Although Letigen has high levels of caffeine (the recommended 3 pills/day are approximately equivalent to caffeine from 6 cups of coffee), periconceptional use does not appear to be associated with an appreciably increased hazard of clinically recognized SAB.",

author = "Howards Penelope and Irva Hertz-Picciotto and Bech, {Bodil Hammer} and N{\o}hr, {Ellen Aagaard} and Andersen, {Anne-Marie Nybo} and Charles Poole and J{\o}rn Olsen",

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doi = "10.1371/journal.pone.0050372",

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TY - JOUR

T1 - Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort

AU - Penelope, Howards

AU - Hertz-Picciotto, Irva

AU - Bech, Bodil Hammer

AU - Nøhr, Ellen Aagaard

AU - Andersen, Anne-Marie Nybo

AU - Poole, Charles

AU - Olsen, Jørn

PY - 2012/11/16

Y1 - 2012/11/16

N2 - Background: Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Danish National Birth Cohort. Methods: Women were recruited during their first prenatal visit from 1996-2002. Pre-conception and early pregnancy medication use was reported on the enrollment form, and pregnancy outcome was determined by linking the mother's Civil Registration Number to the Medical Birth Registry and the National Hospital Discharge Register. Of 97,903 eligible pregnancies, 4,443 ended in SAB between 5 and 20 completed gestational weeks, inclusive. Letigen use was reported for 565 pregnancies. Cox regression models accounting for left truncation were fit to estimate the effect of pre-conception and early pregnancy Letigen use on SAB. Principal Findings: The estimated maternal age-adjusted hazard ratio for SAB was 1.1 (95% confidence interval 0.8-1.6) for any periconceptional Letigen use compared to no periconceptional use. Conclusions: Although Letigen has high levels of caffeine (the recommended 3 pills/day are approximately equivalent to caffeine from 6 cups of coffee), periconceptional use does not appear to be associated with an appreciably increased hazard of clinically recognized SAB.

AB - Background: Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Danish National Birth Cohort. Methods: Women were recruited during their first prenatal visit from 1996-2002. Pre-conception and early pregnancy medication use was reported on the enrollment form, and pregnancy outcome was determined by linking the mother's Civil Registration Number to the Medical Birth Registry and the National Hospital Discharge Register. Of 97,903 eligible pregnancies, 4,443 ended in SAB between 5 and 20 completed gestational weeks, inclusive. Letigen use was reported for 565 pregnancies. Cox regression models accounting for left truncation were fit to estimate the effect of pre-conception and early pregnancy Letigen use on SAB. Principal Findings: The estimated maternal age-adjusted hazard ratio for SAB was 1.1 (95% confidence interval 0.8-1.6) for any periconceptional Letigen use compared to no periconceptional use. Conclusions: Although Letigen has high levels of caffeine (the recommended 3 pills/day are approximately equivalent to caffeine from 6 cups of coffee), periconceptional use does not appear to be associated with an appreciably increased hazard of clinically recognized SAB.

U2 - 10.1371/journal.pone.0050372

DO - 10.1371/journal.pone.0050372

M3 - Journal article

SN - 1932-6203

VL - 7

SP - e50372

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 11

ER -

Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort

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