Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats

Klas S P Abelson; Mahinda Kommalage; A Urban Höglund

doi:10.1016/j.neulet.2004.06.070

Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats

Klas S P Abelson, Mahinda Kommalage, A Urban Höglund

AEM Forskning og Undervisning

9 Citationer (Scopus)

Abstract

Aspirin and paracetamol have been shown to suppress non-inflammatory pain conditions like thermal, visceral and mechanical pain in mice and rats. The non-inflammatory antinociception appears to be mediated by central receptor mechanisms, such as the cholinergic system. In this study, we tested the hypothesis that the non-inflammatory antinociception of aspirin and paracetamol could be mediated by an increase of intraspinal acetylcholine release. Microdialysis probes were placed intraspinally in anesthetized rats for acetylcholine sampling. Subcutaneously administered aspirin 100 and 300 mg/kg increased, while paracetamol 300 mg/kg decreased intraspinal acetylcholine release. Intraspinal drug administration did not affect acetylcholine release. Our results suggest that an increased intraspinal acetylcholine release could be involved in part of the non-inflammatory pain suppression by aspirin, but not by paracetamol.

Originalsprog	Engelsk
Tidsskrift	Neuroscience Letters
Vol/bind	368
Udgave nummer	1
Sider (fra-til)	116-20
Antal sider	5
ISSN	0304-3940
DOI	https://doi.org/10.1016/j.neulet.2004.06.070
Status	Udgivet - 16 sep. 2004

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10.1016/j.neulet.2004.06.070

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title = "Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats",

abstract = "Aspirin and paracetamol have been shown to suppress non-inflammatory pain conditions like thermal, visceral and mechanical pain in mice and rats. The non-inflammatory antinociception appears to be mediated by central receptor mechanisms, such as the cholinergic system. In this study, we tested the hypothesis that the non-inflammatory antinociception of aspirin and paracetamol could be mediated by an increase of intraspinal acetylcholine release. Microdialysis probes were placed intraspinally in anesthetized rats for acetylcholine sampling. Subcutaneously administered aspirin 100 and 300 mg/kg increased, while paracetamol 300 mg/kg decreased intraspinal acetylcholine release. Intraspinal drug administration did not affect acetylcholine release. Our results suggest that an increased intraspinal acetylcholine release could be involved in part of the non-inflammatory pain suppression by aspirin, but not by paracetamol.",

keywords = "Acetaminophen, Acetylcholine, Analgesics, Non-Narcotic, Animals, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Body Temperature, Injections, Subcutaneous, Male, Microdialysis, Pain, Parasympathetic Nervous System, Rats, Rats, Sprague-Dawley, Spinal Cord",

author = "Abelson, {Klas S P} and Mahinda Kommalage and H{\"o}glund, {A Urban}",

year = "2004",

month = sep,

day = "16",

doi = "10.1016/j.neulet.2004.06.070",

language = "English",

volume = "368",

pages = "116--20",

journal = "Neuroscience letters. Supplement",

issn = "0167-6253",

publisher = "Elsevier Ireland Ltd",

number = "1",

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TY - JOUR

T1 - Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats

AU - Abelson, Klas S P

AU - Kommalage, Mahinda

AU - Höglund, A Urban

PY - 2004/9/16

Y1 - 2004/9/16

N2 - Aspirin and paracetamol have been shown to suppress non-inflammatory pain conditions like thermal, visceral and mechanical pain in mice and rats. The non-inflammatory antinociception appears to be mediated by central receptor mechanisms, such as the cholinergic system. In this study, we tested the hypothesis that the non-inflammatory antinociception of aspirin and paracetamol could be mediated by an increase of intraspinal acetylcholine release. Microdialysis probes were placed intraspinally in anesthetized rats for acetylcholine sampling. Subcutaneously administered aspirin 100 and 300 mg/kg increased, while paracetamol 300 mg/kg decreased intraspinal acetylcholine release. Intraspinal drug administration did not affect acetylcholine release. Our results suggest that an increased intraspinal acetylcholine release could be involved in part of the non-inflammatory pain suppression by aspirin, but not by paracetamol.

AB - Aspirin and paracetamol have been shown to suppress non-inflammatory pain conditions like thermal, visceral and mechanical pain in mice and rats. The non-inflammatory antinociception appears to be mediated by central receptor mechanisms, such as the cholinergic system. In this study, we tested the hypothesis that the non-inflammatory antinociception of aspirin and paracetamol could be mediated by an increase of intraspinal acetylcholine release. Microdialysis probes were placed intraspinally in anesthetized rats for acetylcholine sampling. Subcutaneously administered aspirin 100 and 300 mg/kg increased, while paracetamol 300 mg/kg decreased intraspinal acetylcholine release. Intraspinal drug administration did not affect acetylcholine release. Our results suggest that an increased intraspinal acetylcholine release could be involved in part of the non-inflammatory pain suppression by aspirin, but not by paracetamol.

KW - Acetaminophen

KW - Acetylcholine

KW - Analgesics, Non-Narcotic

KW - Animals

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Aspirin

KW - Body Temperature

KW - Injections, Subcutaneous

KW - Male

KW - Microdialysis

KW - Pain

KW - Parasympathetic Nervous System

KW - Rats

KW - Rats, Sprague-Dawley

KW - Spinal Cord

U2 - 10.1016/j.neulet.2004.06.070

DO - 10.1016/j.neulet.2004.06.070

M3 - Journal article

C2 - 15342146

SN - 0167-6253

VL - 368

SP - 116

EP - 120

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

IS - 1

ER -

Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats

Abstract

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