Specific IgE positivity against inhalant allergens and development of autoimmune disease

TY - JOUR

T1 - Specific IgE positivity against inhalant allergens and development of autoimmune disease

AU - Skaaby, Tea

AU - Husemoen, Lise Lotte Nystrup

AU - Thuesen, Betina Heinsbæk

AU - Fenger, Runa Vavia

AU - Linneberg, Allan

PY - 2015/8/1

Y1 - 2015/8/1

N2 - BACKGROUND: Allergic and autoimmune diseases have been suggested to be inversely associated. We investigated the association between atopy and development of any and specific types of autoimmune disease.METHODS: We included a total of 14,849 individuals from five population-based studies with measurements of atopy defined as specific IgE positivity against inhalant allergens. We followed the participants by linkage to the Danish National Patient Register (median follow-up time 11.2 years). Hazard ratio (HR) and 95% confidence interval (CI) of autoimmune disease were estimated by Cox regression.RESULTS: The risk for atopics versus non-atopics was: for any autoimmune disease (HR = 0.99, 95% CI: 0.83, 1.18), thyrotoxicosis (HR = 0.69, 95% CI: 0.34, 1.37), type 1 diabetes (HR = 1.16, 95% CI: 0.84, 1.60), multiple sclerosis (HR = 1.97, 95% CI: 0.95, 4.11), iridocyclitis (HR = 0.82, 95% CI: 0.38, 1.74), Crohn's disease (HR = 1.03, 95% CI: 0.47, 2.25), ulcerative colitis (HR = 0.93, 95% CI: 0.52, 1.69), psoriasis vulgaris (HR = 1.50, 95% CI: 0.86, 2.62), seropositive rheumatoid arthritis (HR = 0.74, 95% CI: 0.48, 1.14) and polymyalgia rheumatica (HR = 0.79, 95% CI: 0.44, 1.44).CONCLUSIONS: We found no statistically significant associations between atopy and autoimmune disease, but we cannot exclude relatively small to moderate effects - protective or promotive - of atopy on autoimmune disease.

AB - BACKGROUND: Allergic and autoimmune diseases have been suggested to be inversely associated. We investigated the association between atopy and development of any and specific types of autoimmune disease.METHODS: We included a total of 14,849 individuals from five population-based studies with measurements of atopy defined as specific IgE positivity against inhalant allergens. We followed the participants by linkage to the Danish National Patient Register (median follow-up time 11.2 years). Hazard ratio (HR) and 95% confidence interval (CI) of autoimmune disease were estimated by Cox regression.RESULTS: The risk for atopics versus non-atopics was: for any autoimmune disease (HR = 0.99, 95% CI: 0.83, 1.18), thyrotoxicosis (HR = 0.69, 95% CI: 0.34, 1.37), type 1 diabetes (HR = 1.16, 95% CI: 0.84, 1.60), multiple sclerosis (HR = 1.97, 95% CI: 0.95, 4.11), iridocyclitis (HR = 0.82, 95% CI: 0.38, 1.74), Crohn's disease (HR = 1.03, 95% CI: 0.47, 2.25), ulcerative colitis (HR = 0.93, 95% CI: 0.52, 1.69), psoriasis vulgaris (HR = 1.50, 95% CI: 0.86, 2.62), seropositive rheumatoid arthritis (HR = 0.74, 95% CI: 0.48, 1.14) and polymyalgia rheumatica (HR = 0.79, 95% CI: 0.44, 1.44).CONCLUSIONS: We found no statistically significant associations between atopy and autoimmune disease, but we cannot exclude relatively small to moderate effects - protective or promotive - of atopy on autoimmune disease.

KW - Adolescent

KW - Adult

KW - Aged

KW - Allergens

KW - Antibody Specificity

KW - Autoimmune Diseases

KW - Denmark

KW - Female

KW - Humans

KW - Hypersensitivity

KW - Immunoglobulin E

KW - Male

KW - Middle Aged

KW - Population Surveillance

KW - Proportional Hazards Models

KW - Registries

KW - Risk Factors

KW - Surveys and Questionnaires

KW - Young Adult

U2 - 10.3109/08916934.2014.1003640

DO - 10.3109/08916934.2014.1003640

M3 - Journal article

C2 - 25600125

SN - 0891-6934

VL - 48

SP - 282

EP - 288

JO - Autoimmunity

JF - Autoimmunity

IS - 5

ER -