Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants

Keyphrases

• High Affinity 100%
• Antidepressants 100%
• Serotonin Transporter 100%
• Citalopram 83%
• Phenylalanine 66%
• Methionine 66%
• Psychostimulants 33%
• Paroxetine 33%
• Tyrosine 33%
• Imipramine 33%
• Species Selectivity 33%
• Fluoxetine 33%
• Functional Groups 16%
• Binding Pocket 16%
• Reuptake 16%
• Pharmacological Profile 16%
• COS Cells 16%
• Beta-blockers 16%
• Extracellular Space 16%
• Chimera 16%
• IC50 Value 16%
• Sodium Chloride 16%
• Neurotransmitter Transporter 16%
• Sertraline 16%
• Fluvoxamine 16%
• Clinically Significant 16%
• Kinetic Parameters 16%
• Cocaine Analog 16%
• Cross-species Analysis 16%
• Cocaine 16%
• Transient Expression 16%
• Serotonin 16%
• Tropane 16%
• 3,4-methylenedioxymethamphetamine 16%
• Molecular Interactions 16%
• Human mutations 16%
• Serotonin Uptake 16%

Neuroscience

• Mutagenesis 100%
• Serotonin Transporter 100%
• Antidepressant 100%
• Citalopram 83%
• Phenylalanine 66%
• Methionine 66%
• Paroxetine 33%
• Fluoxetine 33%
• Imipramine 33%
• Psychostimulant 33%
• Sodium Chloride 16%
• Functional Group 16%
• Neurotransmitter Transporter 16%
• Tropane 16%
• MDMA 16%
• Transient Expression 16%
• Serotonin 16%
• Reuptake 16%
• Sertraline 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Mutagenesis 100%
• Antidepressant 100%
• Serotonin Transporter 100%
• Citalopram 83%
• Phenylalanine 66%
• Methionine 66%
• Fluoxetine 33%
• Serotonin 33%
• Imipramine 33%
• Psychostimulant 33%
• Paroxetine 33%
• Functional Group 16%
• Table Salt 16%
• Neurotransmitter Transporter 16%
• Sertraline 16%
• Tropane Derivative 16%
• MDMA 16%