Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus

Jan Olaf Mirko Härter; Kim Sneppen

doi:10.1128/mBio.00126-12

Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus

Jan Olaf Mirko Härter, Kim Sneppen

Biokompleksitet

34 Citationer (Scopus)

Abstract

Even within similar bacterial strains, it has been found that the clustered, regularly interspaced short palindromic repeat (CRISPR) shows a large variability of spacers. Modeling bacterial strains with different levels of immunity to infection by a single virulent phage, we find that coexistence in a well-mixed environment is possible only when these levels are distinctly different. When bacterial strains are similar, one subpopulation collapses. In the case of bacteria with various levels of CRISPR immunity to a range of phages, small differences in spacer composition will accordingly be suppressed under well-mixed conditions. Using a numerical model of populations spreading in space, we predict that it is the Lamarckian nature of CRISPR evolution that combines with spatial correlations to sustain the experimentally observed distribution of spacer diversity.

Originalsprog	Engelsk
Tidsskrift	mBio
Vol/bind	3
Udgave nummer	4
Sider (fra-til)	e00126
ISSN	2161-2129
DOI	https://doi.org/10.1128/mBio.00126-12
Status	Udgivet - 1 aug. 2012

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10.1128/mBio.00126-12

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title = "Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus",

abstract = "Even within similar bacterial strains, it has been found that the clustered, regularly interspaced short palindromic repeat (CRISPR) shows a large variability of spacers. Modeling bacterial strains with different levels of immunity to infection by a single virulent phage, we find that coexistence in a well-mixed environment is possible only when these levels are distinctly different. When bacterial strains are similar, one subpopulation collapses. In the case of bacteria with various levels of CRISPR immunity to a range of phages, small differences in spacer composition will accordingly be suppressed under well-mixed conditions. Using a numerical model of populations spreading in space, we predict that it is the Lamarckian nature of CRISPR evolution that combines with spatial correlations to sustain the experimentally observed distribution of spacer diversity.",

author = "H{\"a}rter, {Jan Olaf Mirko} and Kim Sneppen",

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T1 - Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus

AU - Härter, Jan Olaf Mirko

AU - Sneppen, Kim

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Even within similar bacterial strains, it has been found that the clustered, regularly interspaced short palindromic repeat (CRISPR) shows a large variability of spacers. Modeling bacterial strains with different levels of immunity to infection by a single virulent phage, we find that coexistence in a well-mixed environment is possible only when these levels are distinctly different. When bacterial strains are similar, one subpopulation collapses. In the case of bacteria with various levels of CRISPR immunity to a range of phages, small differences in spacer composition will accordingly be suppressed under well-mixed conditions. Using a numerical model of populations spreading in space, we predict that it is the Lamarckian nature of CRISPR evolution that combines with spatial correlations to sustain the experimentally observed distribution of spacer diversity.

AB - Even within similar bacterial strains, it has been found that the clustered, regularly interspaced short palindromic repeat (CRISPR) shows a large variability of spacers. Modeling bacterial strains with different levels of immunity to infection by a single virulent phage, we find that coexistence in a well-mixed environment is possible only when these levels are distinctly different. When bacterial strains are similar, one subpopulation collapses. In the case of bacteria with various levels of CRISPR immunity to a range of phages, small differences in spacer composition will accordingly be suppressed under well-mixed conditions. Using a numerical model of populations spreading in space, we predict that it is the Lamarckian nature of CRISPR evolution that combines with spatial correlations to sustain the experimentally observed distribution of spacer diversity.

U2 - 10.1128/mBio.00126-12

DO - 10.1128/mBio.00126-12

M3 - Journal article

SN - 2161-2129

VL - 3

SP - e00126

JO - mBio

JF - mBio

IS - 4

ER -

Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus

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