Solid-phase synthesis of small molecule libraries using double combinatorial chemistry

John Nielsen; Flemming R. Jensen

doi:10.1016/S0040-4039(97)00219-0

Solid-phase synthesis of small molecule libraries using double combinatorial chemistry

John Nielsen^*, Flemming R. Jensen

^*Corresponding author af dette arbejde

21 Citationer (Scopus)

Abstract

The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstrated. The resulting library of model compounds was verified by LC-MS analysis.

Originalsprog	Engelsk
Tidsskrift	Tetrahedron Letters
Vol/bind	38
Udgave nummer	11
Sider (fra-til)	2011-2014
Antal sider	4
ISSN	0040-4039
DOI	https://doi.org/10.1016/S0040-4039(97)00219-0
Status	Udgivet - 17 mar. 1997

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10.1016/S0040-4039(97)00219-0

http://www.scopus.com/inward/record.url?scp=0031575797&partnerID=8YFLogxK

Citationsformater

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AU - Jensen, Flemming R.

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AB - The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstrated. The resulting library of model compounds was verified by LC-MS analysis.

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DO - 10.1016/S0040-4039(97)00219-0

M3 - Journal article

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SN - 0040-4039

VL - 38

SP - 2011

EP - 2014

JO - Tetrahedron Letters

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ER -

Solid-phase synthesis of small molecule libraries using double combinatorial chemistry

Abstract

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