SNARE Requirements En Route to Exocytosis: from Many to Few

TY - JOUR

T1 - SNARE Requirements En Route to Exocytosis

T2 - from Many to Few

AU - Mohrmann, Ralf

AU - Sørensen, Jakob Balslev

PY - 2012/10

Y1 - 2012/10

N2 - Although it has been known for almost two decades that the ternary complex of N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) constitutes the functional unit driving membrane fusion, our knowledge about the dynamical arrangement and organization of SNARE proteins and their complexes before and during vesicle exocytosis is still limited. Here, we review recent progress in this expanding field with emphasis on the question of fusion complex stoichiometry, i.e., how many SNARE proteins and complexes are needed for the fusion of a vesicle with the plasma membrane.

AB - Although it has been known for almost two decades that the ternary complex of N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) constitutes the functional unit driving membrane fusion, our knowledge about the dynamical arrangement and organization of SNARE proteins and their complexes before and during vesicle exocytosis is still limited. Here, we review recent progress in this expanding field with emphasis on the question of fusion complex stoichiometry, i.e., how many SNARE proteins and complexes are needed for the fusion of a vesicle with the plasma membrane.

U2 - 10.1007/s12031-012-9744-2

DO - 10.1007/s12031-012-9744-2

M3 - Review

C2 - 22427188

SN - 0895-8696

SP - 387

EP - 394

JO - Journal of Molecular Neuroscience

JF - Journal of Molecular Neuroscience

ER -