Skeletal muscle as an immunogenic organ

TY - JOUR

T1 - Skeletal muscle as an immunogenic organ

AU - Nielsen, Søren

AU - Pedersen, Bente Klarlund

PY - 2008/6/1

Y1 - 2008/6/1

N2 - During the past few years, a possible link between skeletal muscle contractile activity and immune changes has been established. This concept is based on the finding that exercise provokes an increase in a number of cytokines. We have suggested that cytokines and other peptides that are produced; expressed and released by muscle fibers and exert either paracrine or endocrine effects should be classified as 'myokines'. Human skeletal muscle has the capacity to express several myokines belonging to distinct different cytokine classes and contractile activity plays a role in regulating the expression of cytokines in skeletal muscle. In the present review, we focus on the myokines interleukin (IL)-6, IL-8 and IL-15 and their possible anti-inflammatory, immunoregulatory and metabolic roles.

AB - During the past few years, a possible link between skeletal muscle contractile activity and immune changes has been established. This concept is based on the finding that exercise provokes an increase in a number of cytokines. We have suggested that cytokines and other peptides that are produced; expressed and released by muscle fibers and exert either paracrine or endocrine effects should be classified as 'myokines'. Human skeletal muscle has the capacity to express several myokines belonging to distinct different cytokine classes and contractile activity plays a role in regulating the expression of cytokines in skeletal muscle. In the present review, we focus on the myokines interleukin (IL)-6, IL-8 and IL-15 and their possible anti-inflammatory, immunoregulatory and metabolic roles.

KW - Exercise

KW - Glucose

KW - Humans

KW - Inflammation

KW - Interleukin-15

KW - Interleukin-6

KW - Interleukin-8

KW - Muscle, Skeletal

U2 - 10.1016/j.coph.2008.02.005

DO - 10.1016/j.coph.2008.02.005

M3 - Journal article

C2 - 18417420

SN - 1471-4892

VL - 8

SP - 346

EP - 351

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

IS - 3

ER -