Site-selective three-component reaction for dual-functionalization of peptides

Henrik Kofoed Munch; Jakob Ewald Rasmussen; Gina Popa; Jørn Bolstad Christensen; K.J. Jensen

doi:10.1039/c3cc38673b

Site-selective three-component reaction for dual-functionalization of peptides

Henrik Kofoed Munch, Jakob Ewald Rasmussen, Gina Popa, Jørn Bolstad Christensen, K.J. Jensen

Kemisk Institut

6 Citationer (Scopus)

Abstract

A site-selective dual-functionalization of peptides is presented, involving readily available maleimides as well as N-hydroxylamines. The modification proceeds through a three component 1,3-dipolar cycloaddition, forming a stable product. This was exemplified by the one-pot attachment of two molecular imaging moieties to a tumor binding cyclic peptide, and was extended to the conjugation of a DOTA chelator to a 12 kDa protein.

Originalsprog	Engelsk
Tidsskrift	Chemical Communications
Vol/bind	49
Udgave nummer	19
Sider (fra-til)	1936-1938
Antal sider	3
ISSN	1359-7345
DOI	https://doi.org/10.1039/c3cc38673b
Status	Udgivet - 7 feb. 2013

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abstract = "A site-selective dual-functionalization of peptides is presented, involving readily available maleimides as well as N-hydroxylamines. The modification proceeds through a three component 1,3-dipolar cycloaddition, forming a stable product. This was exemplified by the one-pot attachment of two molecular imaging moieties to a tumor binding cyclic peptide, and was extended to the conjugation of a DOTA chelator to a 12 kDa protein.",

author = "Munch, {Henrik Kofoed} and Rasmussen, {Jakob Ewald} and Gina Popa and Christensen, {J{\o}rn Bolstad} and K.J. Jensen",

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AU - Munch, Henrik Kofoed

AU - Rasmussen, Jakob Ewald

AU - Popa, Gina

AU - Christensen, Jørn Bolstad

AU - Jensen, K.J.

PY - 2013/2/7

Y1 - 2013/2/7

N2 - A site-selective dual-functionalization of peptides is presented, involving readily available maleimides as well as N-hydroxylamines. The modification proceeds through a three component 1,3-dipolar cycloaddition, forming a stable product. This was exemplified by the one-pot attachment of two molecular imaging moieties to a tumor binding cyclic peptide, and was extended to the conjugation of a DOTA chelator to a 12 kDa protein.

AB - A site-selective dual-functionalization of peptides is presented, involving readily available maleimides as well as N-hydroxylamines. The modification proceeds through a three component 1,3-dipolar cycloaddition, forming a stable product. This was exemplified by the one-pot attachment of two molecular imaging moieties to a tumor binding cyclic peptide, and was extended to the conjugation of a DOTA chelator to a 12 kDa protein.

UR - http://www.scopus.com/inward/record.url?scp=84873673638&partnerID=8YFLogxK

U2 - 10.1039/c3cc38673b

DO - 10.1039/c3cc38673b

M3 - Journal article

C2 - 23370690

AN - SCOPUS:84873673638

SN - 1359-7345

VL - 49

SP - 1936

EP - 1938

JO - Chemical Communications

JF - Chemical Communications

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ER -

Site-selective three-component reaction for dual-functionalization of peptides

Abstract

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