TY - JOUR
T1 - Single- vs. double-dose gadolinium contrast in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in knee osteoarthritis
T2 - is dose reduction possible on 3-T MRI?
AU - Hangaard, Stine
AU - Gade, Jesper Sörensson
AU - Hansen, Philip
AU - Damm Nybing, Janus
AU - Gudbergsen, Henrik
AU - Bliddal, Henning
AU - Boesen, Mikael
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background: Reduction in gadolinium (Gd) contrast agents is wanted due to the uncertainty of the potential side effects. Purpose: To investigate whether it is possible to reduce the contrast dose from conventional double dose to single dose when increasing the field strength from 1.5-T to 3-T for separating early cartilage degeneration from healthy cartilage, assessed by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). Material and Methods: Nine patients with knee osteoarthritis (OA), Kellgren–Lawrence grade (KLG) 1–4, were recruited from an ongoing weight loss cohort study. dGEMRIC was performed at 3-T using single (0.1 mmoI/kg) and double (0.2 mmoI/kg) doses of intravenous (i.v.) Gd-DTPA2-. Regions of interest (ROls) were drawn around the posterior weight-bearing femoral knee cartilage in lateral and medial compartments. In five medial compartments ROIs could not be drawn due to severe degeneration of cartilage. T1-relaxation times were compared to previously published values from 1.5-T and to non-contrast values from 3-T. Results: Mean dGEMRIC T1-relaxation time in the lateral compartment was 769 ms for single dose vs. 561 ms for double dose (P < 0.0001); and 685 ms for single dose vs. 454 ms for double dose (P = 0.004) in the medial compartment. Conclusion: We found a dose-response relationship between single and double doses of Gd-DTPA2- using 3-T in knee OA patients, similar to the findings at 1.5-T. Compared to the T1-relaxation time at 3-T without contrast (1240 ms), this further separation between OA and normal cartilage indicates that “single dose” dGEMRIC could be sufficient for cartilage health assessment at 3-T.
AB - Background: Reduction in gadolinium (Gd) contrast agents is wanted due to the uncertainty of the potential side effects. Purpose: To investigate whether it is possible to reduce the contrast dose from conventional double dose to single dose when increasing the field strength from 1.5-T to 3-T for separating early cartilage degeneration from healthy cartilage, assessed by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). Material and Methods: Nine patients with knee osteoarthritis (OA), Kellgren–Lawrence grade (KLG) 1–4, were recruited from an ongoing weight loss cohort study. dGEMRIC was performed at 3-T using single (0.1 mmoI/kg) and double (0.2 mmoI/kg) doses of intravenous (i.v.) Gd-DTPA2-. Regions of interest (ROls) were drawn around the posterior weight-bearing femoral knee cartilage in lateral and medial compartments. In five medial compartments ROIs could not be drawn due to severe degeneration of cartilage. T1-relaxation times were compared to previously published values from 1.5-T and to non-contrast values from 3-T. Results: Mean dGEMRIC T1-relaxation time in the lateral compartment was 769 ms for single dose vs. 561 ms for double dose (P < 0.0001); and 685 ms for single dose vs. 454 ms for double dose (P = 0.004) in the medial compartment. Conclusion: We found a dose-response relationship between single and double doses of Gd-DTPA2- using 3-T in knee OA patients, similar to the findings at 1.5-T. Compared to the T1-relaxation time at 3-T without contrast (1240 ms), this further separation between OA and normal cartilage indicates that “single dose” dGEMRIC could be sufficient for cartilage health assessment at 3-T.
U2 - 10.1177/0284185118796694
DO - 10.1177/0284185118796694
M3 - Journal article
C2 - 30142997
SN - 0365-5954
VL - 60
SP - 749
EP - 754
JO - Acta Radiologica - Series Diagnosis
JF - Acta Radiologica - Series Diagnosis
IS - 6
ER -