Simulating haplotype blocks in the human genome

TY - JOUR

T1 - Simulating haplotype blocks in the human genome

AU - Posada, David

AU - Wiuf, Carsten

PY - 2003/2/1

Y1 - 2003/2/1

N2 - A bioinformatic tool was written to simulate haplotypes and SNPs under a modified coalescent with recombination. The most important feature of this program is that it allows for the specification of non-homogeneous recombination rates, which results in the formation of the so-called 'haplotype blocks' of the human genome. The program also implements different mutation models and flexible demographic histories. The samples generated can be very useful to better understand the architecture of the human genome and to investigate its impact in association studies searching for disease genes.

AB - A bioinformatic tool was written to simulate haplotypes and SNPs under a modified coalescent with recombination. The most important feature of this program is that it allows for the specification of non-homogeneous recombination rates, which results in the formation of the so-called 'haplotype blocks' of the human genome. The program also implements different mutation models and flexible demographic histories. The samples generated can be very useful to better understand the architecture of the human genome and to investigate its impact in association studies searching for disease genes.

UR - http://www.scopus.com/inward/record.url?scp=0037314075&partnerID=8YFLogxK

U2 - 10.1093/bioinformatics/19.2.289

DO - 10.1093/bioinformatics/19.2.289

M3 - Journal article

C2 - 12538254

AN - SCOPUS:0037314075

SN - 1367-4811

VL - 19

SP - 289

EP - 290

JO - Bioinformatics (Online)

JF - Bioinformatics (Online)

IS - 2

ER -