TY - JOUR
T1 - Significant one week efficacy of a calcipotriol plus betamethasone dipropionate scalp formulation
AU - Jemec, G.B.E.
AU - Van De Kerkhof, P.C.M.
AU - Enevold, A.
AU - Ganslandt, C.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background A two-compound scalp formulation containing calcipotriol (50 μg/g) and betamethasone (0.5 mg/g; as dipropionate) (Xamiol®, Taclonex Scalp®) has been shown to be an effective and safe treatment for scalp psoriasis. Objective The aim of this study was to investigate the clinical efficacy of the two-compound scalp formulation after 1 week of treatment. Methods Pooled data from two large pivotal phase III trials with 2920 patients receiving once-daily treatment for up to 8 weeks with either the two-compound scalp formulation (n = 1108), betamethasone dipropionate (n = 1118), calcipotriol (n = 558), or the vehicle (n = 136) were analysed. Results The percentage of patients who had 'absent' or 'very mild' disease according to Investigator's Global Assessment after 1 week of treatment was significantly higher with the two-compound scalp formulation (30.6%) compared to betamethasone (24.1%; P < 0.001), calcipotriol (10.0%; P < 0.001) or vehicle (6.9%; P < 0.001). Conclusion This data indicates that the two-compound scalp formulation demonstrated significant efficacy already after 1 week, with a faster onset of effect than either of the individual components in the same vehicle, in the treatment of scalp psoriasis.
AB - Background A two-compound scalp formulation containing calcipotriol (50 μg/g) and betamethasone (0.5 mg/g; as dipropionate) (Xamiol®, Taclonex Scalp®) has been shown to be an effective and safe treatment for scalp psoriasis. Objective The aim of this study was to investigate the clinical efficacy of the two-compound scalp formulation after 1 week of treatment. Methods Pooled data from two large pivotal phase III trials with 2920 patients receiving once-daily treatment for up to 8 weeks with either the two-compound scalp formulation (n = 1108), betamethasone dipropionate (n = 1118), calcipotriol (n = 558), or the vehicle (n = 136) were analysed. Results The percentage of patients who had 'absent' or 'very mild' disease according to Investigator's Global Assessment after 1 week of treatment was significantly higher with the two-compound scalp formulation (30.6%) compared to betamethasone (24.1%; P < 0.001), calcipotriol (10.0%; P < 0.001) or vehicle (6.9%; P < 0.001). Conclusion This data indicates that the two-compound scalp formulation demonstrated significant efficacy already after 1 week, with a faster onset of effect than either of the individual components in the same vehicle, in the treatment of scalp psoriasis.
UR - http://www.scopus.com/inward/record.url?scp=78649988545&partnerID=8YFLogxK
U2 - 10.1111/j.1468-3083.2010.03682.x
DO - 10.1111/j.1468-3083.2010.03682.x
M3 - Journal article
C2 - 20456557
AN - SCOPUS:78649988545
SN - 0926-9959
VL - 25
SP - 27
EP - 32
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 1
ER -