Signalling molecules, growth regulators and cell cycle control in Drosophila

TY - JOUR

T1 - Signalling molecules, growth regulators and cell cycle control in Drosophila

AU - Herranz, Héctor

AU - Milán, Marco

PY - 2008/11/1

Y1 - 2008/11/1

N2 - During the development of a given organ or tissue within a multicellular organism, growth and patterning are controlled in a coordinated manner by the activity of a discrete number of signalling molecules and their corresponding pathways to give rise to a well-formed structure with a particular size, shape and pattern. Understanding how cells of different tissues or organs translate the activity of these pathways into an activation or repression of the cell cycle machinery in a context-dependent manner is at present one of the most intriguing questions in developmental and cancer biology. In this article we review the different roles of the Notch and Wingless signalling molecules in the regulation of cell cycle progression in the developing eye and wing imaginal discs of Drosophila and propose that, depending on how growth regulators are controlled in a context-dependent manner by the activity of these pathways, signalling molecules might have tumour suppressor or oncogene activity.

AB - During the development of a given organ or tissue within a multicellular organism, growth and patterning are controlled in a coordinated manner by the activity of a discrete number of signalling molecules and their corresponding pathways to give rise to a well-formed structure with a particular size, shape and pattern. Understanding how cells of different tissues or organs translate the activity of these pathways into an activation or repression of the cell cycle machinery in a context-dependent manner is at present one of the most intriguing questions in developmental and cancer biology. In this article we review the different roles of the Notch and Wingless signalling molecules in the regulation of cell cycle progression in the developing eye and wing imaginal discs of Drosophila and propose that, depending on how growth regulators are controlled in a context-dependent manner by the activity of these pathways, signalling molecules might have tumour suppressor or oncogene activity.

KW - Animals

KW - Cell Cycle

KW - Drosophila Proteins

KW - Drosophila melanogaster

KW - Intercellular Signaling Peptides and Proteins

KW - Signal Transduction

KW - Wing

M3 - Journal article

C2 - 18948741

SN - 1538-4101

VL - 7

SP - 3335

EP - 3337

JO - Cell Cycle

JF - Cell Cycle

IS - 21

ER -