Signaling pathways regulating murine pancreatic development

TY - JOUR

T1 - Signaling pathways regulating murine pancreatic development

AU - Serup, Palle

N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - The recent decades have seen a huge expansion in our knowledge about pancreatic development. Numerous lineage-restricted transcription factor genes have been identified and much has been learned about their function. Similarly, numerous signaling pathways important for pancreas development have been identified and the specific roles have been investigated by genetic and cell biological methods. The present review presents an overview of the principal signaling pathways involved in regulating murine pancreatic growth, morphogenesis, and cell differentiation.

AB - The recent decades have seen a huge expansion in our knowledge about pancreatic development. Numerous lineage-restricted transcription factor genes have been identified and much has been learned about their function. Similarly, numerous signaling pathways important for pancreas development have been identified and the specific roles have been investigated by genetic and cell biological methods. The present review presents an overview of the principal signaling pathways involved in regulating murine pancreatic growth, morphogenesis, and cell differentiation.

KW - Animals

KW - Epithelium

KW - Mesoderm

KW - Mice

KW - Organogenesis

KW - Pancreas

KW - Receptor Protein-Tyrosine Kinases

KW - Signal Transduction

U2 - 10.1016/j.semcdb.2012.06.004

DO - 10.1016/j.semcdb.2012.06.004

M3 - Review

C2 - 22728666

SN - 1084-9521

VL - 23

SP - 663

EP - 672

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 6

ER -