Signaling in migrating neurons: from molecules to networks

TY - JOUR

T1 - Signaling in migrating neurons

T2 - from molecules to networks

AU - Khodosevich, Konstantin

AU - Monyer, Hannah

PY - 2011

Y1 - 2011

N2 - During prenatal and postnatal development of the mammalian brain, new neurons are generated by precursor cells that are located in the germinal zones. Subsequently newborn neurons migrate to their destined location in the brain. On the migrational route immature neurons interact via a series of recognition molecules with a plethora of extracellular cues. Stimuli that are conveyed by extracellular cues are translated into complex intracellular signaling networks that eventually enable neuronal migration. In this Focused Review we discuss signaling networks underlying neuronal migration emphasizing molecules and pathways that appear to be neuron-specific.

AB - During prenatal and postnatal development of the mammalian brain, new neurons are generated by precursor cells that are located in the germinal zones. Subsequently newborn neurons migrate to their destined location in the brain. On the migrational route immature neurons interact via a series of recognition molecules with a plethora of extracellular cues. Stimuli that are conveyed by extracellular cues are translated into complex intracellular signaling networks that eventually enable neuronal migration. In this Focused Review we discuss signaling networks underlying neuronal migration emphasizing molecules and pathways that appear to be neuron-specific.

U2 - 10.3389/fnins.2011.00028

DO - 10.3389/fnins.2011.00028

M3 - Journal article

C2 - 21629825

SN - 1662-4548

VL - 5

SP - 28

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

ER -