Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels

TY - JOUR

T1 - Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels

AU - Russo, R E

AU - Hounsgaard, J

PY - 1994/7/1

Y1 - 1994/7/1

N2 - Windup--the gradual increase of the response--of dorsal horn neurons to repeated activation of primary afferents is an elementary form of short-term plasticity that may mediate central sensitization to pain. In deep dorsal horn neurons of the turtle spinal cord in vitro we report windup of the response to repeated depolarizing current pulses as well as to repeated stimulation of the ipsilateral dorsal root. We found both forms of windup to be mediated by a depolarizing potential produced by increasing activation of postsynaptic L-type Ca2+ channels. These results suggest a central role for intrinsic postsynaptic properties in nociceptive plasticity and for L-type Ca2+ channels as a promising target for therapeutic intervention.

AB - Windup--the gradual increase of the response--of dorsal horn neurons to repeated activation of primary afferents is an elementary form of short-term plasticity that may mediate central sensitization to pain. In deep dorsal horn neurons of the turtle spinal cord in vitro we report windup of the response to repeated depolarizing current pulses as well as to repeated stimulation of the ipsilateral dorsal root. We found both forms of windup to be mediated by a depolarizing potential produced by increasing activation of postsynaptic L-type Ca2+ channels. These results suggest a central role for intrinsic postsynaptic properties in nociceptive plasticity and for L-type Ca2+ channels as a promising target for therapeutic intervention.

KW - Action Potentials

KW - Afferent Pathways

KW - Animals

KW - Calcium Channels

KW - Neuronal Plasticity

KW - Neurons

KW - Pain

KW - Spinal Cord

KW - Turtles

M3 - Journal article

C2 - 7969900

SN - 0306-4522

VL - 61

SP - 191

EP - 197

JO - Neuroscience

JF - Neuroscience

IS - 2

ER -