Short mandible – a possible risk factor for cleft palate with/without a cleft lip

TY - JOUR

T1 - Short mandible – a possible risk factor for cleft palate with/without a cleft lip

AU - Hermann, N. V.

AU - Darvann, T. A.

AU - Ersbøll, B. K.

AU - Kreiborg, S.

PY - 2014/5

Y1 - 2014/5

N2 - Structured Abstract: Objectives: To estimate the influence of a short mandible on the risk of developing a cleft palate with/without a cleft lip (CP). Setting and sample population: The retrospective sample consisted of 115 2-month-old Danish infants with CP, and 70 control infants with unilateral incomplete cleft lip (UICL). Material and Methods: Cephalometric X-rays were obtained. Mandibular length (Lm) was measured and corrected for body length (Lb) to remove influence of varying body length in the sample. Logistic regression was applied to the corrected mandibular length (Lmc) to calculate the risk of having a cleft palate. Results: The mean mandibular length in the group with CP was about 4 mm shorter than in the control group. Odds ratio (OR) was calculated to be 0.58 (95% confidence interval 0.48-0.68), implying that an individual's risk of cleft palate with/without a cleft lip increases about 50% per mm decrease in mandibular length. Conclusions: A special facial type including a short mandible is a possible risk factor for cleft palate, and it was found that the risk of cleft palate increases 58% per mm decreases in mandibular length.

AB - Structured Abstract: Objectives: To estimate the influence of a short mandible on the risk of developing a cleft palate with/without a cleft lip (CP). Setting and sample population: The retrospective sample consisted of 115 2-month-old Danish infants with CP, and 70 control infants with unilateral incomplete cleft lip (UICL). Material and Methods: Cephalometric X-rays were obtained. Mandibular length (Lm) was measured and corrected for body length (Lb) to remove influence of varying body length in the sample. Logistic regression was applied to the corrected mandibular length (Lmc) to calculate the risk of having a cleft palate. Results: The mean mandibular length in the group with CP was about 4 mm shorter than in the control group. Odds ratio (OR) was calculated to be 0.58 (95% confidence interval 0.48-0.68), implying that an individual's risk of cleft palate with/without a cleft lip increases about 50% per mm decrease in mandibular length. Conclusions: A special facial type including a short mandible is a possible risk factor for cleft palate, and it was found that the risk of cleft palate increases 58% per mm decreases in mandibular length.

KW - Cleft palate

KW - Mandible

KW - Risk factor

U2 - 10.1111/ocr.12036

DO - 10.1111/ocr.12036

M3 - Journal article

C2 - 24397533

AN - SCOPUS:84897937079

SN - 1601-6335

VL - 17

SP - 106

EP - 114

JO - Clinical orthodontics and research

JF - Clinical orthodontics and research

IS - 2

ER -