Sexual rehabilitation for cardiac patients with erectile dysfunction: A randomised clinical trial

Pernille Palm; Ann Dorthe Olsen Zwisler; Jesper Hastrup Svendsen; Lau Casper Thygesen; Annamaria Giraldi; Karina Gregersen Jensen; Jane Lindschou; Per Winkel; Christian Gluud; Elaine Steinke; Selina Kikkenborg Berg

doi:10.1136/heartjnl-2018-313778

Sexual rehabilitation for cardiac patients with erectile dysfunction: A randomised clinical trial

Pernille Palm^*, Ann Dorthe Olsen Zwisler, Jesper Hastrup Svendsen, Lau Casper Thygesen, Annamaria Giraldi, Karina Gregersen Jensen, Jane Lindschou, Per Winkel, Christian Gluud, Elaine Steinke, Selina Kikkenborg Berg

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

3 Citationer (Scopus)

Abstract

Background Sexual dysfunction is common in patients with either ischaemic heart disease (IHD) or implantable cardioverter defibrillator (ICD) and has a negative impact on quality of life. Non-pharmacological treatment options are lacking. The purpose of this trial was to assess the effect of sexual rehabilitation versus usual care for males with erectile dysfunction and either IHD and/or ICD. Methods Participants with erectile dysfunction and IHD and/or ICD were randomised to 12 weeks of sexual rehabilitation consisting of physical exercise training, pelvic floor exercise and psychoeducation, or usual care. Primary outcome: Sexual function by the International Index of Erectile Function (IIEF). Secondary outcome: Sexual function by the Psychosocial Adjustment to Illness Scale. Exploratory outcomes: Exercise capacity, pelvic floor strength/endurance, self-reported health and mental health. Results 154 participants were included, mean age 61.6 years (SD 6.1). Sexual rehabilitation compared with usual care improved sexual function with a mean difference IIEF score of 6.7 (95% CI 3.1 to 10.4, p<0.0003) at 4 months between groups (unadjusted IIEF mean scores 36.4 vs 31.3) and a mean difference of 6.7, 95% CI 3.2 to 10.1 (p<0.0002) at 6 months between groups (unadjusted mean scores IIEF 37.1 vs 32.2). No effects were seen on the secondary outcome. Sexual rehabilitation improved exercise capacity on cycle ergometer measured by Watt max with a mean difference of 10.3, 95% CI 3.6 to 16.9 (p<0.003) and pelvic floor strength (p<0.01). No differences were seen on self-reported health and mental health. Conclusion Sexual rehabilitation compared with usual care improves sexual function and exercise capacity.

Originalsprog	Engelsk
Tidsskrift	Heart
Vol/bind	105
Udgave nummer	10
Sider (fra-til)	775-782
Antal sider	8
ISSN	1355-6037
DOI	https://doi.org/10.1136/heartjnl-2018-313778
Status	Udgivet - 2019

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10.1136/heartjnl-2018-313778

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@article{41243f7d99a14dcba4b3a7d55471236f,

title = "Sexual rehabilitation for cardiac patients with erectile dysfunction: A randomised clinical trial",

abstract = "Background Sexual dysfunction is common in patients with either ischaemic heart disease (IHD) or implantable cardioverter defibrillator (ICD) and has a negative impact on quality of life. Non-pharmacological treatment options are lacking. The purpose of this trial was to assess the effect of sexual rehabilitation versus usual care for males with erectile dysfunction and either IHD and/or ICD. Methods Participants with erectile dysfunction and IHD and/or ICD were randomised to 12 weeks of sexual rehabilitation consisting of physical exercise training, pelvic floor exercise and psychoeducation, or usual care. Primary outcome: Sexual function by the International Index of Erectile Function (IIEF). Secondary outcome: Sexual function by the Psychosocial Adjustment to Illness Scale. Exploratory outcomes: Exercise capacity, pelvic floor strength/endurance, self-reported health and mental health. Results 154 participants were included, mean age 61.6 years (SD 6.1). Sexual rehabilitation compared with usual care improved sexual function with a mean difference IIEF score of 6.7 (95% CI 3.1 to 10.4, p<0.0003) at 4 months between groups (unadjusted IIEF mean scores 36.4 vs 31.3) and a mean difference of 6.7, 95% CI 3.2 to 10.1 (p<0.0002) at 6 months between groups (unadjusted mean scores IIEF 37.1 vs 32.2). No effects were seen on the secondary outcome. Sexual rehabilitation improved exercise capacity on cycle ergometer measured by Watt max with a mean difference of 10.3, 95% CI 3.6 to 16.9 (p<0.003) and pelvic floor strength (p<0.01). No differences were seen on self-reported health and mental health. Conclusion Sexual rehabilitation compared with usual care improves sexual function and exercise capacity.",

keywords = "cardiac rehabilitation, coronary artery disease, implanted cardiac defibrillators",

author = "Pernille Palm and Zwisler, {Ann Dorthe Olsen} and Svendsen, {Jesper Hastrup} and Thygesen, {Lau Casper} and Annamaria Giraldi and Jensen, {Karina Gregersen} and Jane Lindschou and Per Winkel and Christian Gluud and Elaine Steinke and Berg, {Selina Kikkenborg}",

year = "2019",

doi = "10.1136/heartjnl-2018-313778",

language = "English",

volume = "105",

pages = "775--782",

journal = "Heart",

issn = "1355-6037",

publisher = "B M J Group",

number = "10",

}

TY - JOUR

T1 - Sexual rehabilitation for cardiac patients with erectile dysfunction

T2 - A randomised clinical trial

AU - Palm, Pernille

AU - Zwisler, Ann Dorthe Olsen

AU - Svendsen, Jesper Hastrup

AU - Thygesen, Lau Casper

AU - Giraldi, Annamaria

AU - Jensen, Karina Gregersen

AU - Lindschou, Jane

AU - Winkel, Per

AU - Gluud, Christian

AU - Steinke, Elaine

AU - Berg, Selina Kikkenborg

PY - 2019

Y1 - 2019

N2 - Background Sexual dysfunction is common in patients with either ischaemic heart disease (IHD) or implantable cardioverter defibrillator (ICD) and has a negative impact on quality of life. Non-pharmacological treatment options are lacking. The purpose of this trial was to assess the effect of sexual rehabilitation versus usual care for males with erectile dysfunction and either IHD and/or ICD. Methods Participants with erectile dysfunction and IHD and/or ICD were randomised to 12 weeks of sexual rehabilitation consisting of physical exercise training, pelvic floor exercise and psychoeducation, or usual care. Primary outcome: Sexual function by the International Index of Erectile Function (IIEF). Secondary outcome: Sexual function by the Psychosocial Adjustment to Illness Scale. Exploratory outcomes: Exercise capacity, pelvic floor strength/endurance, self-reported health and mental health. Results 154 participants were included, mean age 61.6 years (SD 6.1). Sexual rehabilitation compared with usual care improved sexual function with a mean difference IIEF score of 6.7 (95% CI 3.1 to 10.4, p<0.0003) at 4 months between groups (unadjusted IIEF mean scores 36.4 vs 31.3) and a mean difference of 6.7, 95% CI 3.2 to 10.1 (p<0.0002) at 6 months between groups (unadjusted mean scores IIEF 37.1 vs 32.2). No effects were seen on the secondary outcome. Sexual rehabilitation improved exercise capacity on cycle ergometer measured by Watt max with a mean difference of 10.3, 95% CI 3.6 to 16.9 (p<0.003) and pelvic floor strength (p<0.01). No differences were seen on self-reported health and mental health. Conclusion Sexual rehabilitation compared with usual care improves sexual function and exercise capacity.

AB - Background Sexual dysfunction is common in patients with either ischaemic heart disease (IHD) or implantable cardioverter defibrillator (ICD) and has a negative impact on quality of life. Non-pharmacological treatment options are lacking. The purpose of this trial was to assess the effect of sexual rehabilitation versus usual care for males with erectile dysfunction and either IHD and/or ICD. Methods Participants with erectile dysfunction and IHD and/or ICD were randomised to 12 weeks of sexual rehabilitation consisting of physical exercise training, pelvic floor exercise and psychoeducation, or usual care. Primary outcome: Sexual function by the International Index of Erectile Function (IIEF). Secondary outcome: Sexual function by the Psychosocial Adjustment to Illness Scale. Exploratory outcomes: Exercise capacity, pelvic floor strength/endurance, self-reported health and mental health. Results 154 participants were included, mean age 61.6 years (SD 6.1). Sexual rehabilitation compared with usual care improved sexual function with a mean difference IIEF score of 6.7 (95% CI 3.1 to 10.4, p<0.0003) at 4 months between groups (unadjusted IIEF mean scores 36.4 vs 31.3) and a mean difference of 6.7, 95% CI 3.2 to 10.1 (p<0.0002) at 6 months between groups (unadjusted mean scores IIEF 37.1 vs 32.2). No effects were seen on the secondary outcome. Sexual rehabilitation improved exercise capacity on cycle ergometer measured by Watt max with a mean difference of 10.3, 95% CI 3.6 to 16.9 (p<0.003) and pelvic floor strength (p<0.01). No differences were seen on self-reported health and mental health. Conclusion Sexual rehabilitation compared with usual care improves sexual function and exercise capacity.

KW - cardiac rehabilitation

KW - coronary artery disease

KW - implanted cardiac defibrillators

U2 - 10.1136/heartjnl-2018-313778

DO - 10.1136/heartjnl-2018-313778

M3 - Journal article

C2 - 30381319

AN - SCOPUS:85056092797

SN - 1355-6037

VL - 105

SP - 775

EP - 782

JO - Heart

JF - Heart

IS - 10

ER -

Sexual rehabilitation for cardiac patients with erectile dysfunction: A randomised clinical trial

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