Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men

TY - JOUR

T1 - Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men

AU - Lapauw, Bruno

AU - Ouwens, Margriet

AU - 't Hart, Leen M

AU - Wuyts, Birgitte

AU - Holst, Jens Juul

AU - T'Sjoen, Guy

AU - Kaufman, Jean-Marc

AU - Ruige, Johannes B

PY - 2010/8/1

Y1 - 2010/8/1

N2 - OBJECTIVE - To evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition. RESEARCH DESIGN AND METHODS - A randomized clinical trial was performed to create contrasting sex steroid levels in healthy young men: by letrozole (aromatase inhibitor) to lower estradiol (E 2) and increase testosterone (group T, n = 10) versus letrozole plus E 2 patches to lower T and raise E 2 (group E, n = 10). Mixed meals and hyperinsulinemic-euglycemic clamps were performed before and after a 1-week treatment period. RESULTS - Following intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E. CONCLUSIONS - In healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity.

AB - OBJECTIVE - To evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition. RESEARCH DESIGN AND METHODS - A randomized clinical trial was performed to create contrasting sex steroid levels in healthy young men: by letrozole (aromatase inhibitor) to lower estradiol (E 2) and increase testosterone (group T, n = 10) versus letrozole plus E 2 patches to lower T and raise E 2 (group E, n = 10). Mixed meals and hyperinsulinemic-euglycemic clamps were performed before and after a 1-week treatment period. RESULTS - Following intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E. CONCLUSIONS - In healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity.

U2 - 10.2337/dc10-0515

DO - 10.2337/dc10-0515

M3 - Journal article

C2 - 20484128

SN - 0149-5992

VL - 33

SP - 1831

EP - 1833

JO - Diabetes Care

JF - Diabetes Care

IS - 8

ER -