Serotonergic modulation of spinal motor control

Jean-Francois Marie Perrier; Florence Cotel

doi:10.1016/j.conb.2014.12.008

Serotonergic modulation of spinal motor control

Jean-Francois Marie Perrier, Florence Cotel

Neuronal Signalling

42 Citationer (Scopus)

Abstract

Serotonin (5-HT) is a monoamine that powerfully modulates spinal motor control by acting on intrasynaptic and extrasynaptic receptors. Here we review the diversity of 5-HT actions on locomotor and motoneuronal activities. Two approaches have been used on in vitro spinal cord preparations: either applying 5-HT in the extracellular medium or inducing its synaptic release. They produced strikingly different results suggesting that the net effect of 5-HT depends on the identity of the activated receptors and their location. Recent findings suggest that moderate release of 5-HT facilitates locomotion and promotes the excitability of motoneurons, while stronger release inhibits rhythmic activity and motoneuron firing. This latter effect is responsible for central fatigue and secures rotation of motor units.

Originalsprog	Engelsk
Tidsskrift	Current Opinion in Neurobiology
Vol/bind	33
Sider (fra-til)	1-7
Antal sider	7
ISSN	0959-4388
DOI	https://doi.org/10.1016/j.conb.2014.12.008
Status	Udgivet - 1 jan. 2015

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10.1016/j.conb.2014.12.008

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abstract = "Serotonin (5-HT) is a monoamine that powerfully modulates spinal motor control by acting on intrasynaptic and extrasynaptic receptors. Here we review the diversity of 5-HT actions on locomotor and motoneuronal activities. Two approaches have been used on in vitro spinal cord preparations: either applying 5-HT in the extracellular medium or inducing its synaptic release. They produced strikingly different results suggesting that the net effect of 5-HT depends on the identity of the activated receptors and their location. Recent findings suggest that moderate release of 5-HT facilitates locomotion and promotes the excitability of motoneurons, while stronger release inhibits rhythmic activity and motoneuron firing. This latter effect is responsible for central fatigue and secures rotation of motor units.",

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AU - Cotel, Florence

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AB - Serotonin (5-HT) is a monoamine that powerfully modulates spinal motor control by acting on intrasynaptic and extrasynaptic receptors. Here we review the diversity of 5-HT actions on locomotor and motoneuronal activities. Two approaches have been used on in vitro spinal cord preparations: either applying 5-HT in the extracellular medium or inducing its synaptic release. They produced strikingly different results suggesting that the net effect of 5-HT depends on the identity of the activated receptors and their location. Recent findings suggest that moderate release of 5-HT facilitates locomotion and promotes the excitability of motoneurons, while stronger release inhibits rhythmic activity and motoneuron firing. This latter effect is responsible for central fatigue and secures rotation of motor units.

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DO - 10.1016/j.conb.2014.12.008

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EP - 7

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

ER -

Serotonergic modulation of spinal motor control

Abstract

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