Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

Daniel F Gudbjartsson; Unnur S Bjornsdottir; Eva Halapi; Anna Helgadottir; Patrick Sulem; Gudrun M Jonsdottir; Gudmar Thorleifsson; Hafdis Helgadottir; Valgerdur Steinthorsdottir; Hreinn Stefansson; Carolyn Williams; Jennie Hui; John Beilby; Nicole M Warrington; Alan James; Lyle J Palmer; Gerard H Koppelman; Andrea Heinzmann; Marcus Krueger; H Marike Boezen; Amanda Wheatley; Janine Altmuller; Hyoung Doo Shin; Soo-Taek Uh; Hyun Sub Cheong; Brynja Jonsdottir; David Gislason; Choon-Sik Park; Linda M Rasmussen; Celeste Porsbjerg; Jakob W Hansen; Vibeke Backer; Thomas Werge; Christer Janson; Ulla-Britt Jönsson; Maggie C Y Ng; Juliana Chan; Wing Yee So; Ronald Ma; Svati H Shah; Christopher B Granger; Arshed A Quyyumi; Allan I Levey; Viola Vaccarino; Muredach P Reilly; Daniel J Rader; Michael J A Williams; Andre M van Rij; Gregory T Jones; Elisabetta Trabetti; Giovanni Malerba; Pier Franco Pignatti; Attilio Boner; Lydia Pescollderungg; Domenico Girelli; Oliviero Olivieri; Nicola Martinelli; Bjorn R Ludviksson; Dora Ludviksdottir; Gudmundur I Eyjolfsson; David Arnar; Gudmundur Thorgeirsson; Klaus Deichmann; Philip J Thompson; Matthias Wjst; Ian P Hall; Dirkje S Postma; Thorarinn Gislason; Jeffrey Gulcher; Augustine Kong; Ingileif Jonsdottir; Unnur Thorsteinsdottir; Kari Stefansson; Daniel F Gudbjartsson; Unnur S Bjornsdottir; Eva Halapi; Anna Helgadottir; Patrick Sulem; Gudrun M Jonsdottir; Gudmar Thorleifsson; Hafdis Helgadottir; Valgerdur Steinthorsdottir; Hreinn Stefansson; Carolyn Williams; Jennie Hui; John Beilby; Nicole M Warrington; Alan James; Lyle J Palmer; Gerard H Koppelman; Andrea Heinzmann; Marcus Krueger; H Marike Boezen; Amanda Wheatley; Janine Altmuller; Hyoung Doo Shin; Soo-Taek Uh; Hyun Sub Cheong; Brynja Jonsdottir; David Gislason; Choon-Sik Park; Linda M Rasmussen; Celeste Michala Porsbjerg; Jakob W Hansen; Vibeke Backer; Thomas Werge; Christer Janson; Ulla-Britt Jönsson; Maggie C Y Ng; Juliana Chan; Wing Yee So; Ronald Ma; Svati H Shah; Christopher B Granger; Arshed A Quyyumi; Allan I Levey; Viola Vaccarino; Muredach P Reilly; Daniel J Rader; Michael J A Williams; Andre M van Rij; Gregory T Jones; Elisabetta Trabetti; Giovanni Malerba; Pier Franco Pignatti; Attilio Boner; Lydia Pescollderungg; Domenico Girelli; Oliviero Olivieri; Nicola Martinelli; Bjorn R Ludviksson; Dora Ludviksdottir; Gudmundur I Eyjolfsson; David Arnar; Gudmundur Thorgeirsson; Klaus Deichmann; Philip J Thompson; Matthias Wjst; Ian P Hall; Dirkje S Postma; Thorarinn Gislason; Jeffrey Gulcher; Augustine Kong; Ingileif Jonsdottir; Unnur Thorsteinsdottir; Kari Stefansson

doi:10.1038/ng.323

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

Daniel F Gudbjartsson, Unnur S Bjornsdottir, Eva Halapi, Anna Helgadottir, Patrick Sulem, Gudrun M Jonsdottir, Gudmar Thorleifsson, Hafdis Helgadottir, Valgerdur Steinthorsdottir, Hreinn Stefansson, Carolyn Williams, Jennie Hui, John Beilby, Nicole M Warrington, Alan James, Lyle J Palmer, Gerard H Koppelman, Andrea Heinzmann, Marcus Krueger, H Marike BoezenAmanda Wheatley, Janine Altmuller, Hyoung Doo Shin, Soo-Taek Uh, Hyun Sub Cheong, Brynja Jonsdottir, David Gislason, Choon-Sik Park, Linda M Rasmussen, Celeste Porsbjerg, Jakob W Hansen, Vibeke Backer, Thomas Werge, Christer Janson, Ulla-Britt Jönsson, Maggie C Y Ng, Juliana Chan, Wing Yee So, Ronald Ma, Svati H Shah, Christopher B Granger, Arshed A Quyyumi, Allan I Levey, Viola Vaccarino, Muredach P Reilly, Daniel J Rader, Michael J A Williams, Andre M van Rij, Gregory T Jones, Elisabetta Trabetti, Giovanni Malerba, Pier Franco Pignatti, Attilio Boner, Lydia Pescollderungg, Domenico Girelli, Oliviero Olivieri, Nicola Martinelli, Bjorn R Ludviksson, Dora Ludviksdottir, Gudmundur I Eyjolfsson, David Arnar, Gudmundur Thorgeirsson, Klaus Deichmann, Philip J Thompson, Matthias Wjst, Ian P Hall, Dirkje S Postma, Thorarinn Gislason, Jeffrey Gulcher, Augustine Kong, Ingileif Jonsdottir, Unnur Thorsteinsdottir, Kari Stefansson, Daniel F Gudbjartsson, Unnur S Bjornsdottir, Eva Halapi, Anna Helgadottir, Patrick Sulem, Gudrun M Jonsdottir, Gudmar Thorleifsson, Hafdis Helgadottir, Valgerdur Steinthorsdottir, Hreinn Stefansson, Carolyn Williams, Jennie Hui, John Beilby, Nicole M Warrington, Alan James, Lyle J Palmer, Gerard H Koppelman, Andrea Heinzmann, Marcus Krueger, H Marike Boezen, Amanda Wheatley, Janine Altmuller, Hyoung Doo Shin, Soo-Taek Uh, Hyun Sub Cheong, Brynja Jonsdottir, David Gislason, Choon-Sik Park, Linda M Rasmussen, Celeste Michala Porsbjerg, Jakob W Hansen, Vibeke Backer, Thomas Werge, Christer Janson, Ulla-Britt Jönsson, Maggie C Y Ng, Juliana Chan, Wing Yee So, Ronald Ma, Svati H Shah, Christopher B Granger, Arshed A Quyyumi, Allan I Levey, Viola Vaccarino, Muredach P Reilly, Daniel J Rader, Michael J A Williams, Andre M van Rij, Gregory T Jones, Elisabetta Trabetti, Giovanni Malerba, Pier Franco Pignatti, Attilio Boner, Lydia Pescollderungg, Domenico Girelli, Oliviero Olivieri, Nicola Martinelli, Bjorn R Ludviksson, Dora Ludviksdottir, Gudmundur I Eyjolfsson, David Arnar, Gudmundur Thorgeirsson, Klaus Deichmann, Philip J Thompson, Matthias Wjst, Ian P Hall, Dirkje S Postma, Thorarinn Gislason, Jeffrey Gulcher, Augustine Kong, Ingileif Jonsdottir, Unnur Thorsteinsdottir, Kari Stefansson

570 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Mar

Originalsprog	Engelsk
Tidsskrift	Nature Genetics
Vol/bind	41
Udgave nummer	3
Sider (fra-til)	342-7
Antal sider	5
ISSN	1061-4036
DOI	https://doi.org/10.1038/ng.323 https://doi.org/10.1038/ng.323
Status	Udgivet - 2009

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Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. M., Thorleifsson, G., Helgadottir, H., Steinthorsdottir, V., Stefansson, H., Williams, C., Hui, J., Beilby, J., Warrington, N. M., James, A., Palmer, L. J., Koppelman, G. H., Heinzmann, A., Krueger, M., ... Stefansson, K. (2009). Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics, 41(3), 342-7. https://doi.org/10.1038/ng.323, https://doi.org/10.1038/ng.323

Gudbjartsson, DF, Bjornsdottir, US, Halapi, E, Helgadottir, A, Sulem, P, Jonsdottir, GM, Thorleifsson, G, Helgadottir, H, Steinthorsdottir, V, Stefansson, H, Williams, C, Hui, J, Beilby, J, Warrington, NM, James, A, Palmer, LJ, Koppelman, GH, Heinzmann, A, Krueger, M, Boezen, HM, Wheatley, A, Altmuller, J, Shin, HD, Uh, S-T, Cheong, HS, Jonsdottir, B, Gislason, D, Park, C-S, Rasmussen, LM, Porsbjerg, C, Hansen, JW, Backer, V , Werge, T, Janson, C, Jönsson, U-B, Ng, MCY, Chan, J, So, WY, Ma, R, Shah, SH, Granger, CB, Quyyumi, AA, Levey, AI, Vaccarino, V, Reilly, MP, Rader, DJ, Williams, MJA, van Rij, AM, Jones, GT, Trabetti, E, Malerba, G, Pignatti, PF, Boner, A, Pescollderungg, L, Girelli, D, Olivieri, O, Martinelli, N, Ludviksson, BR, Ludviksdottir, D, Eyjolfsson, GI, Arnar, D, Thorgeirsson, G, Deichmann, K, Thompson, PJ, Wjst, M, Hall, IP, Postma, DS, Gislason, T, Gulcher, J, Kong, A, Jonsdottir, I, Thorsteinsdottir, U, Stefansson, K, Gudbjartsson, DF, Bjornsdottir, US, Halapi, E, Helgadottir, A, Sulem, P, Jonsdottir, GM, Thorleifsson, G, Helgadottir, H, Steinthorsdottir, V, Stefansson, H, Williams, C, Hui, J, Beilby, J, Warrington, NM, James, A, Palmer, LJ, Koppelman, GH, Heinzmann, A, Krueger, M, Boezen, HM, Wheatley, A, Altmuller, J, Shin, HD, Uh, S-T, Cheong, HS, Jonsdottir, B, Gislason, D, Park, C-S, Rasmussen, LM, Porsbjerg, CM, Hansen, JW, Backer, V , Werge, T, Janson, C, Jönsson, U-B, Ng, MCY, Chan, J, So, WY, Ma, R, Shah, SH, Granger, CB, Quyyumi, AA, Levey, AI, Vaccarino, V, Reilly, MP, Rader, DJ, Williams, MJA, van Rij, AM, Jones, GT, Trabetti, E, Malerba, G, Pignatti, PF, Boner, A, Pescollderungg, L, Girelli, D, Olivieri, O, Martinelli, N, Ludviksson, BR, Ludviksdottir, D, Eyjolfsson, GI, Arnar, D, Thorgeirsson, G, Deichmann, K, Thompson, PJ, Wjst, M, Hall, IP, Postma, DS, Gislason, T, Gulcher, J, Kong, A, Jonsdottir, I, Thorsteinsdottir, U & Stefansson, K 2009, 'Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction', Nature Genetics, bind 41, nr. 3, s. 342-7. https://doi.org/10.1038/ng.323, https://doi.org/10.1038/ng.323

@article{5dc813b0a5f811df928f000ea68e967b,

title = "Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction",

abstract = "Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).",

author = "Gudbjartsson, {Daniel F} and Bjornsdottir, {Unnur S} and Eva Halapi and Anna Helgadottir and Patrick Sulem and Jonsdottir, {Gudrun M} and Gudmar Thorleifsson and Hafdis Helgadottir and Valgerdur Steinthorsdottir and Hreinn Stefansson and Carolyn Williams and Jennie Hui and John Beilby and Warrington, {Nicole M} and Alan James and Palmer, {Lyle J} and Koppelman, {Gerard H} and Andrea Heinzmann and Marcus Krueger and Boezen, {H Marike} and Amanda Wheatley and Janine Altmuller and Shin, {Hyoung Doo} and Soo-Taek Uh and Cheong, {Hyun Sub} and Brynja Jonsdottir and David Gislason and Choon-Sik Park and Rasmussen, {Linda M} and Celeste Porsbjerg and Hansen, {Jakob W} and Vibeke Backer and Thomas Werge and Christer Janson and Ulla-Britt J{\"o}nsson and Ng, {Maggie C Y} and Juliana Chan and So, {Wing Yee} and Ronald Ma and Shah, {Svati H} and Granger, {Christopher B} and Quyyumi, {Arshed A} and Levey, {Allan I} and Viola Vaccarino and Reilly, {Muredach P} and Rader, {Daniel J} and Williams, {Michael J A} and {van Rij}, {Andre M} and Jones, {Gregory T} and Elisabetta Trabetti and Giovanni Malerba and Pignatti, {Pier Franco} and Attilio Boner and Lydia Pescollderungg and Domenico Girelli and Oliviero Olivieri and Nicola Martinelli and Ludviksson, {Bjorn R} and Dora Ludviksdottir and Eyjolfsson, {Gudmundur I} and David Arnar and Gudmundur Thorgeirsson and Klaus Deichmann and Thompson, {Philip J} and Matthias Wjst and Hall, {Ian P} and Postma, {Dirkje S} and Thorarinn Gislason and Jeffrey Gulcher and Augustine Kong and Ingileif Jonsdottir and Unnur Thorsteinsdottir and Kari Stefansson and Gudbjartsson, {Daniel F} and Bjornsdottir, {Unnur S} and Eva Halapi and Anna Helgadottir and Patrick Sulem and Jonsdottir, {Gudrun M} and Gudmar Thorleifsson and Hafdis Helgadottir and Valgerdur Steinthorsdottir and Hreinn Stefansson and Carolyn Williams and Jennie Hui and John Beilby and Warrington, {Nicole M} and Alan James and Palmer, {Lyle J} and Koppelman, {Gerard H} and Andrea Heinzmann and Marcus Krueger and Boezen, {H Marike} and Amanda Wheatley and Janine Altmuller and Shin, {Hyoung Doo} and Soo-Taek Uh and Cheong, {Hyun Sub} and Brynja Jonsdottir and David Gislason and Choon-Sik Park and Rasmussen, {Linda M} and Porsbjerg, {Celeste Michala} and Hansen, {Jakob W} and Vibeke Backer and Thomas Werge and Christer Janson and Ulla-Britt J{\"o}nsson and Ng, {Maggie C Y} and Juliana Chan and So, {Wing Yee} and Ronald Ma and Shah, {Svati H} and Granger, {Christopher B} and Quyyumi, {Arshed A} and Levey, {Allan I} and Viola Vaccarino and Reilly, {Muredach P} and Rader, {Daniel J} and Williams, {Michael J A} and {van Rij}, {Andre M} and Jones, {Gregory T} and Elisabetta Trabetti and Giovanni Malerba and Pignatti, {Pier Franco} and Attilio Boner and Lydia Pescollderungg and Domenico Girelli and Oliviero Olivieri and Nicola Martinelli and Ludviksson, {Bjorn R} and Dora Ludviksdottir and Eyjolfsson, {Gudmundur I} and David Arnar and Gudmundur Thorgeirsson and Klaus Deichmann and Thompson, {Philip J} and Matthias Wjst and Hall, {Ian P} and Postma, {Dirkje S} and Thorarinn Gislason and Jeffrey Gulcher and Augustine Kong and Ingileif Jonsdottir and Unnur Thorsteinsdottir and Kari Stefansson",

note = "Keywords: Adaptor Proteins, Vesicular Transport; Algorithms; Asthma; Case-Control Studies; Eosinophils; Eye Proteins; Genes, myb; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Iceland; Interleukins; Leukocyte Count; Myocardial Infarction; Polymorphism, Single Nucleotide; Proteins; Receptors, Cell Surface",

year = "2009",

doi = "10.1038/ng.323",

language = "English",

volume = "41",

pages = "342--7",

journal = "Nature: New biology",

issn = "1061-4036",

publisher = "nature publishing group",

number = "3",

}

TY - JOUR

T1 - Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

AU - Gudbjartsson, Daniel F

AU - Bjornsdottir, Unnur S

AU - Halapi, Eva

AU - Helgadottir, Anna

AU - Sulem, Patrick

AU - Jonsdottir, Gudrun M

AU - Thorleifsson, Gudmar

AU - Helgadottir, Hafdis

AU - Steinthorsdottir, Valgerdur

AU - Stefansson, Hreinn

AU - Williams, Carolyn

AU - Hui, Jennie

AU - Beilby, John

AU - Warrington, Nicole M

AU - James, Alan

AU - Palmer, Lyle J

AU - Koppelman, Gerard H

AU - Heinzmann, Andrea

AU - Krueger, Marcus

AU - Boezen, H Marike

AU - Wheatley, Amanda

AU - Altmuller, Janine

AU - Shin, Hyoung Doo

AU - Uh, Soo-Taek

AU - Cheong, Hyun Sub

AU - Jonsdottir, Brynja

AU - Gislason, David

AU - Park, Choon-Sik

AU - Rasmussen, Linda M

AU - Porsbjerg, Celeste

AU - Hansen, Jakob W

AU - Backer, Vibeke

AU - Werge, Thomas

AU - Janson, Christer

AU - Jönsson, Ulla-Britt

AU - Ng, Maggie C Y

AU - Chan, Juliana

AU - So, Wing Yee

AU - Ma, Ronald

AU - Shah, Svati H

AU - Granger, Christopher B

AU - Quyyumi, Arshed A

AU - Levey, Allan I

AU - Vaccarino, Viola

AU - Reilly, Muredach P

AU - Rader, Daniel J

AU - Williams, Michael J A

AU - van Rij, Andre M

AU - Jones, Gregory T

AU - Trabetti, Elisabetta

AU - Malerba, Giovanni

AU - Pignatti, Pier Franco

AU - Boner, Attilio

AU - Pescollderungg, Lydia

AU - Girelli, Domenico

AU - Olivieri, Oliviero

AU - Martinelli, Nicola

AU - Ludviksson, Bjorn R

AU - Ludviksdottir, Dora

AU - Eyjolfsson, Gudmundur I

AU - Arnar, David

AU - Thorgeirsson, Gudmundur

AU - Deichmann, Klaus

AU - Thompson, Philip J

AU - Wjst, Matthias

AU - Hall, Ian P

AU - Postma, Dirkje S

AU - Gislason, Thorarinn

AU - Gulcher, Jeffrey

AU - Kong, Augustine

AU - Jonsdottir, Ingileif

AU - Thorsteinsdottir, Unnur

AU - Stefansson, Kari

AU - Gudbjartsson, Daniel F

AU - Bjornsdottir, Unnur S

AU - Halapi, Eva

AU - Helgadottir, Anna

AU - Sulem, Patrick

AU - Jonsdottir, Gudrun M

AU - Thorleifsson, Gudmar

AU - Helgadottir, Hafdis

AU - Steinthorsdottir, Valgerdur

AU - Stefansson, Hreinn

AU - Williams, Carolyn

AU - Hui, Jennie

AU - Beilby, John

AU - Warrington, Nicole M

AU - James, Alan

AU - Palmer, Lyle J

AU - Koppelman, Gerard H

AU - Heinzmann, Andrea

AU - Krueger, Marcus

AU - Boezen, H Marike

AU - Wheatley, Amanda

AU - Altmuller, Janine

AU - Shin, Hyoung Doo

AU - Uh, Soo-Taek

AU - Cheong, Hyun Sub

AU - Jonsdottir, Brynja

AU - Gislason, David

AU - Park, Choon-Sik

AU - Rasmussen, Linda M

AU - Porsbjerg, Celeste Michala

AU - Hansen, Jakob W

AU - Backer, Vibeke

AU - Werge, Thomas

AU - Janson, Christer

AU - Jönsson, Ulla-Britt

AU - Ng, Maggie C Y

AU - Chan, Juliana

AU - So, Wing Yee

AU - Ma, Ronald

AU - Shah, Svati H

AU - Granger, Christopher B

AU - Quyyumi, Arshed A

AU - Levey, Allan I

AU - Vaccarino, Viola

AU - Reilly, Muredach P

AU - Rader, Daniel J

AU - Williams, Michael J A

AU - van Rij, Andre M

AU - Jones, Gregory T

AU - Trabetti, Elisabetta

AU - Malerba, Giovanni

AU - Pignatti, Pier Franco

AU - Boner, Attilio

AU - Pescollderungg, Lydia

AU - Girelli, Domenico

AU - Olivieri, Oliviero

AU - Martinelli, Nicola

AU - Ludviksson, Bjorn R

AU - Ludviksdottir, Dora

AU - Eyjolfsson, Gudmundur I

AU - Arnar, David

AU - Thorgeirsson, Gudmundur

AU - Deichmann, Klaus

AU - Thompson, Philip J

AU - Wjst, Matthias

AU - Hall, Ian P

AU - Postma, Dirkje S

AU - Gislason, Thorarinn

AU - Gulcher, Jeffrey

AU - Kong, Augustine

AU - Jonsdottir, Ingileif

AU - Thorsteinsdottir, Unnur

AU - Stefansson, Kari

N1 - Keywords: Adaptor Proteins, Vesicular Transport; Algorithms; Asthma; Case-Control Studies; Eosinophils; Eye Proteins; Genes, myb; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Iceland; Interleukins; Leukocyte Count; Myocardial Infarction; Polymorphism, Single Nucleotide; Proteins; Receptors, Cell Surface

PY - 2009

Y1 - 2009

N2 - Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).

AB - Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).

U2 - 10.1038/ng.323

DO - 10.1038/ng.323

M3 - Journal article

C2 - 19198610

SN - 1061-4036

VL - 41

SP - 342

EP - 347

JO - Nature: New biology

JF - Nature: New biology

IS - 3

ER -

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

Abstract

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