TY - JOUR
T1 - Sepsis
T2 - frontiers in diagnosis, resuscitation and antibiotic therapy
AU - Perner, Anders
AU - Gordon, Anthony C
AU - De Backer, Daniel
AU - Dimopoulos, George
AU - Russell, James A
AU - Lipman, Jeffrey
AU - Jensen, Jens-Ulrik
AU - Myburgh, John
AU - Singer, Mervyn
AU - Bellomo, Rinaldo
AU - Walsh, Timothy S
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Sepsis is a major growing global burden and a major challenge to intensive care clinicians, researchers, guideline committee members and policy makers, because of its high and increasing incidence and great pathophysiological, molecular, genetic and clinical complexity. In spite of recent progress, short-term mortality remains high and there is growing evidence of long-term morbidity and increased long-term mortality in survivors of sepsis both in developed and developing countries. Further improvement in the care of patients with sepsis will impact upon global health. In this narrative review, invited experts describe the expected challenges and progress to be made in the near future. We focus on diagnosis, resuscitation (fluids, vasopressors, inotropes, blood transfusion and hemodynamic targets) and infection (antibiotics and infection biomarkers), as these areas are key, if initial management and subsequent outcomes are to be improved in patients with sepsis.
AB - Sepsis is a major growing global burden and a major challenge to intensive care clinicians, researchers, guideline committee members and policy makers, because of its high and increasing incidence and great pathophysiological, molecular, genetic and clinical complexity. In spite of recent progress, short-term mortality remains high and there is growing evidence of long-term morbidity and increased long-term mortality in survivors of sepsis both in developed and developing countries. Further improvement in the care of patients with sepsis will impact upon global health. In this narrative review, invited experts describe the expected challenges and progress to be made in the near future. We focus on diagnosis, resuscitation (fluids, vasopressors, inotropes, blood transfusion and hemodynamic targets) and infection (antibiotics and infection biomarkers), as these areas are key, if initial management and subsequent outcomes are to be improved in patients with sepsis.
KW - Review
KW - Journal Article
U2 - 10.1007/s00134-016-4577-z
DO - 10.1007/s00134-016-4577-z
M3 - Review
C2 - 27695884
SN - 0935-1701
VL - 42
SP - 1958
EP - 1969
JO - European Journal of Intensive Care Medicine
JF - European Journal of Intensive Care Medicine
IS - 12
ER -