Sensor-Augmented Insulin Pumps and Hypoglycemia Prevention in Type 1 Diabetes

Isabelle Steineck; Ajenthen Ranjan; Kirsten Nørgaard; Signe Schmidt

doi:10.1177/1932296816672689

Sensor-Augmented Insulin Pumps and Hypoglycemia Prevention in Type 1 Diabetes

Isabelle Steineck, Ajenthen Ranjan, Kirsten Nørgaard, Signe Schmidt

Institut for Klinisk Medicin

22 Citationer (Scopus)

Abstract

Hypoglycemia can lead to seizures, unconsciousness, or death. Insulin pump treatment reduces the frequency of severe hypoglycemia compared with multiple daily injections treatment. The addition of a continuous glucose monitor, so-called sensor-augmented pump (SAP) treatment, has the potential to further limit the duration and severity of hypoglycemia as the system can detect and in some systems act on impending and prevailing low blood glucose levels. In this narrative review we summarize the available knowledge on SAPs with and without automated insulin suspension, in relation to hypoglycemia prevention. We present evidence from randomized trials, observational studies, and meta-analyses including nonpregnant individuals with type 1 diabetes mellitus. We also outline concerns regarding SAPs with and without automated insulin suspension. There is evidence that SAP treatment reduces episodes of moderate and severe hypoglycemia compared with multiple daily injections plus self-monitoring of blood glucose. There is some evidence that SAPs both with and without automated suspension reduces the frequency of severe hypoglycemic events compared with insulin pumps without continuous glucose monitoring.

Originalsprog	Engelsk
Tidsskrift	Journal of Diabetes Science and Technology
Vol/bind	11
Udgave nummer	1
Sider (fra-til)	50-58
Antal sider	9
ISSN	1932-2968
DOI	https://doi.org/10.1177/1932296816672689
Status	Udgivet - 1 jan. 2017

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10.1177/1932296816672689

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N2 - Hypoglycemia can lead to seizures, unconsciousness, or death. Insulin pump treatment reduces the frequency of severe hypoglycemia compared with multiple daily injections treatment. The addition of a continuous glucose monitor, so-called sensor-augmented pump (SAP) treatment, has the potential to further limit the duration and severity of hypoglycemia as the system can detect and in some systems act on impending and prevailing low blood glucose levels. In this narrative review we summarize the available knowledge on SAPs with and without automated insulin suspension, in relation to hypoglycemia prevention. We present evidence from randomized trials, observational studies, and meta-analyses including nonpregnant individuals with type 1 diabetes mellitus. We also outline concerns regarding SAPs with and without automated insulin suspension. There is evidence that SAP treatment reduces episodes of moderate and severe hypoglycemia compared with multiple daily injections plus self-monitoring of blood glucose. There is some evidence that SAPs both with and without automated suspension reduces the frequency of severe hypoglycemic events compared with insulin pumps without continuous glucose monitoring.

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Sensor-Augmented Insulin Pumps and Hypoglycemia Prevention in Type 1 Diabetes

Abstract

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