Sensing danger: Toll-like receptors and outcome in allogeneic hematopoietic stem cell transplantation

TY - JOUR

T1 - Sensing danger

T2 - Toll-like receptors and outcome in allogeneic hematopoietic stem cell transplantation

AU - Kornblit, B.

AU - Müller, K.

PY - 2017

Y1 - 2017

N2 - Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) play key roles in initiating innate and adaptive immune responses. Based mainly on animal studies there is growing evidence to suggest that TLRs are involved in the development of chemotherapy-induced mucositis and in the propagation of graft versus host reactions as well as graft versus tumor effects in allogeneic hematopoietic stem cell transplantation (HSCT). In this review we discuss these findings along with the emerging, although still preliminary, clinical evidence, that points to a role of PRRs in determining the outcome of HSCT and new therapeutic perspectives that may be related to this development.

AB - Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) play key roles in initiating innate and adaptive immune responses. Based mainly on animal studies there is growing evidence to suggest that TLRs are involved in the development of chemotherapy-induced mucositis and in the propagation of graft versus host reactions as well as graft versus tumor effects in allogeneic hematopoietic stem cell transplantation (HSCT). In this review we discuss these findings along with the emerging, although still preliminary, clinical evidence, that points to a role of PRRs in determining the outcome of HSCT and new therapeutic perspectives that may be related to this development.

U2 - 10.1038/bmt.2016.263

DO - 10.1038/bmt.2016.263

M3 - Review

C2 - 27941769

AN - SCOPUS:85016989364

SN - 0268-3369

VL - 52

SP - 499

EP - 505

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

ER -