Semi-quantitative myocardial perfusion measured by computed tomography in patients with refractory angina: a head-to-head comparison with quantitative rubidium-82 positron emission tomography as reference

TY - JOUR

T1 - Semi-quantitative myocardial perfusion measured by computed tomography in patients with refractory angina

T2 - a head-to-head comparison with quantitative rubidium-82 positron emission tomography as reference

AU - Qayyum, Abbas Ali

AU - Kühl, Jørgen Tobias

AU - Kjaer, Andreas

AU - Hasbak, Philip

AU - Kofoed, Klaus Fuglsang

AU - Kastrup, Jens

N1 - © 2015 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

PY - 2017/9

Y1 - 2017/9

N2 - Introduction: Computed tomography (CT) is a novel method for assessment of myocardial perfusion and has not yet been compared to rubidium-82 positron emission tomography (PET). We aimed to compare CT measured semi-quantitative myocardial perfusion with absolute quantified myocardial perfusion using PET and to detect stenotic territories in patients with severe coronary artery disease. Materials and methods: Eighteen patients with stenosis narrowing coronary arteries ≥70% demonstrated on invasive coronary angiography underwent rest and adenosine stress imaging obtained by 320-multidetector CT scanner and CT/PET 64-slice scanner. CT measured myocardial attenuation density (AD) and perfusion index (PI) were correlated to absolute PET myocardial perfusion values. Results: Rest AD, rest and stress PI did not correlate to PET findings (r = 0·412, P = 0·113; r = 0·300, P = 0·259; and r = 0·508, P = 0·064, respectively). However, there was a significant correlation between stress AD and stress PET values (r = 0·670, P = 0·009) and between stress and rest differences for AD and PI with PET differences (r = 0·620, P = 0·006; and r = 0·639, P = 0·004, respectively). Furthermore, significant differences were observed between remote and stenotic territories for rest and stress AD (48 ± 14HU and 37 ± 16HU, P = 0·002; 76 ± 19HU and 58 ± 13HU, P<0·001, respectively), PI (9·6 ± 2·9 and 7·5 ± 3·1, P = 0·002; 21·6 ± 4·1 and 16·9 ± 3·9, P<0·001, respectively) and PET (0·96 ± 0·37 ml g−1 min−1 and 0·86 ± 0·26 ml g−1 min−1, P = 0·036; 2·07 ± 0·76 ml g−1 min−1 and 1·61 ± 0·76 ml g−1 min−1, P = 0·006, respectively). Conclusions: Semi-quantitative CT parameters may be useful in the detection of myocardium subtended by stenotic coronary arteries.

AB - Introduction: Computed tomography (CT) is a novel method for assessment of myocardial perfusion and has not yet been compared to rubidium-82 positron emission tomography (PET). We aimed to compare CT measured semi-quantitative myocardial perfusion with absolute quantified myocardial perfusion using PET and to detect stenotic territories in patients with severe coronary artery disease. Materials and methods: Eighteen patients with stenosis narrowing coronary arteries ≥70% demonstrated on invasive coronary angiography underwent rest and adenosine stress imaging obtained by 320-multidetector CT scanner and CT/PET 64-slice scanner. CT measured myocardial attenuation density (AD) and perfusion index (PI) were correlated to absolute PET myocardial perfusion values. Results: Rest AD, rest and stress PI did not correlate to PET findings (r = 0·412, P = 0·113; r = 0·300, P = 0·259; and r = 0·508, P = 0·064, respectively). However, there was a significant correlation between stress AD and stress PET values (r = 0·670, P = 0·009) and between stress and rest differences for AD and PI with PET differences (r = 0·620, P = 0·006; and r = 0·639, P = 0·004, respectively). Furthermore, significant differences were observed between remote and stenotic territories for rest and stress AD (48 ± 14HU and 37 ± 16HU, P = 0·002; 76 ± 19HU and 58 ± 13HU, P<0·001, respectively), PI (9·6 ± 2·9 and 7·5 ± 3·1, P = 0·002; 21·6 ± 4·1 and 16·9 ± 3·9, P<0·001, respectively) and PET (0·96 ± 0·37 ml g−1 min−1 and 0·86 ± 0·26 ml g−1 min−1, P = 0·036; 2·07 ± 0·76 ml g−1 min−1 and 1·61 ± 0·76 ml g−1 min−1, P = 0·006, respectively). Conclusions: Semi-quantitative CT parameters may be useful in the detection of myocardium subtended by stenotic coronary arteries.

U2 - 10.1111/cpf.12322

DO - 10.1111/cpf.12322

M3 - Journal article

C2 - 26625937

SN - 1475-0961

VL - 37

SP - 481

EP - 488

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 5

ER -