TY - JOUR
T1 - Semen Quality as a Predictor of Subsequent Morbidity
T2 - A Danish Cohort Study of 4,712 Men with Long-Term Follow-up
AU - Latif, Tabassam
AU - Jensen, Tina Kold
AU - Mehlsen, Jesper
AU - Holmboe, Stine Agergaard
AU - Brinth, Louise
AU - Skouby, Sven Olaf
AU - Jørgensen, Niels
AU - Lindahl-Jacobsen, Rune
PY - 2017
Y1 - 2017
N2 - Semen quality has been suggested to be a biologicalmarker of long-term morbidity and mortality; however, few studies have been conducted on this subject. We identified 5,370 men seen for infertility at Frederiksberg Hospital, Denmark, during 1977-2010, and 4,712 of thesemen were followed in the Danish National Patient Registry until first hospitalization, death, or the end of the study.We classified patients according to hospitalizations and the presence of cardiovascular disease, diabetes, testicular cancer, or prostate cancer. We found a clear association between sperm concentration below 15million/mL and all-cause hospitalizations (hazard ratio = 1.5, 95% confidence interval: 1.4, 1.6) and cardiovascular disease (hazard ratio = 1.4, 95% confidence interval: 1.2, 1.6), compared with men with a concentration above 40million/ mL. The probabilities for hospitalizations were also higher with a low total sperm count and low motility. Men with a sperm concentration of 195-200million/mL were, on average, hospitalized for the first time 7 years later than were men with a sperm concentration of 0-5million/mL. Semen quality was associated with long-term morbidity, and a significantly higher risk of hospitalization was found, in particular for cardiovascular diseases and diabetes mellitus. Our study supports the suggestion that semen quality is a strong biomarker of general health.
AB - Semen quality has been suggested to be a biologicalmarker of long-term morbidity and mortality; however, few studies have been conducted on this subject. We identified 5,370 men seen for infertility at Frederiksberg Hospital, Denmark, during 1977-2010, and 4,712 of thesemen were followed in the Danish National Patient Registry until first hospitalization, death, or the end of the study.We classified patients according to hospitalizations and the presence of cardiovascular disease, diabetes, testicular cancer, or prostate cancer. We found a clear association between sperm concentration below 15million/mL and all-cause hospitalizations (hazard ratio = 1.5, 95% confidence interval: 1.4, 1.6) and cardiovascular disease (hazard ratio = 1.4, 95% confidence interval: 1.2, 1.6), compared with men with a concentration above 40million/ mL. The probabilities for hospitalizations were also higher with a low total sperm count and low motility. Men with a sperm concentration of 195-200million/mL were, on average, hospitalized for the first time 7 years later than were men with a sperm concentration of 0-5million/mL. Semen quality was associated with long-term morbidity, and a significantly higher risk of hospitalization was found, in particular for cardiovascular diseases and diabetes mellitus. Our study supports the suggestion that semen quality is a strong biomarker of general health.
KW - Cardiovascular disease
KW - Diabetes
KW - Hospitalization
KW - Prostate cancer
KW - Sperm concentration
KW - Testicular cancer
KW - Total sperm count
U2 - 10.1093/aje/kwx067
DO - 10.1093/aje/kwx067
M3 - Journal article
C2 - 28498890
AN - SCOPUS:85031915930
SN - 0002-9262
VL - 186
SP - 910
EP - 917
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 8
ER -
