Semantic memory impairment in the earliest phases of Alzheimer's disease

Asmus Vogel; Anders Gade; Jette Stokholm; Gunhild Waldemar

doi:http://dx.doi.org/10.1159/000082352

Semantic memory impairment in the earliest phases of Alzheimer's disease

Asmus Vogel, Anders Gade, Jette Stokholm, Gunhild Waldemar

Institut for Klinisk Medicin

86 Citationer (Scopus)

Abstract

The presence and the nature of semantic memory dysfunction in Alzheimer's disease (AD) have been widely debated. This study aimed to determine the frequency of impaired semantic test performances in mild AD and to study whether incipient semantic impairments could be identified in predementia AD. Five short neuropsychological tests sensitive to semantic memory and easily applicable in routine practice were administered to 102 patients with mild AD (Mini-Mental State Examination score above 19), 22 predementia AD patients and 58 healthy subjects. 'Category fluency' and 'naming of famous faces' were the most frequently impaired tests in both patient groups. The study demonstrated that impairments on semantically related tests are common in mild AD and may exist prior to the clinical diagnosis. The results imply that assessment of semantic memory is relevant in the evaluation of patients with suspected AD.

Originalsprog	Engelsk
Tidsskrift	Dementia and Geriatric Cognitive Disorders
Vol/bind	19
Udgave nummer	2-3
Sider (fra-til)	75-81
Antal sider	7
ISSN	1420-8008
DOI	https://doi.org/10.1159/000082352
Status	Udgivet - 2005

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http://dx.doi.org/10.1159/000082352

Citationsformater

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abstract = "The presence and the nature of semantic memory dysfunction in Alzheimer's disease (AD) have been widely debated. This study aimed to determine the frequency of impaired semantic test performances in mild AD and to study whether incipient semantic impairments could be identified in predementia AD. Five short neuropsychological tests sensitive to semantic memory and easily applicable in routine practice were administered to 102 patients with mild AD (Mini-Mental State Examination score above 19), 22 predementia AD patients and 58 healthy subjects. 'Category fluency' and 'naming of famous faces' were the most frequently impaired tests in both patient groups. The study demonstrated that impairments on semantically related tests are common in mild AD and may exist prior to the clinical diagnosis. The results imply that assessment of semantic memory is relevant in the evaluation of patients with suspected AD.",

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T1 - Semantic memory impairment in the earliest phases of Alzheimer's disease

AU - Vogel, Asmus

AU - Gade, Anders

AU - Stokholm, Jette

AU - Waldemar, Gunhild

PY - 2005

Y1 - 2005

N2 - The presence and the nature of semantic memory dysfunction in Alzheimer's disease (AD) have been widely debated. This study aimed to determine the frequency of impaired semantic test performances in mild AD and to study whether incipient semantic impairments could be identified in predementia AD. Five short neuropsychological tests sensitive to semantic memory and easily applicable in routine practice were administered to 102 patients with mild AD (Mini-Mental State Examination score above 19), 22 predementia AD patients and 58 healthy subjects. 'Category fluency' and 'naming of famous faces' were the most frequently impaired tests in both patient groups. The study demonstrated that impairments on semantically related tests are common in mild AD and may exist prior to the clinical diagnosis. The results imply that assessment of semantic memory is relevant in the evaluation of patients with suspected AD.

AB - The presence and the nature of semantic memory dysfunction in Alzheimer's disease (AD) have been widely debated. This study aimed to determine the frequency of impaired semantic test performances in mild AD and to study whether incipient semantic impairments could be identified in predementia AD. Five short neuropsychological tests sensitive to semantic memory and easily applicable in routine practice were administered to 102 patients with mild AD (Mini-Mental State Examination score above 19), 22 predementia AD patients and 58 healthy subjects. 'Category fluency' and 'naming of famous faces' were the most frequently impaired tests in both patient groups. The study demonstrated that impairments on semantically related tests are common in mild AD and may exist prior to the clinical diagnosis. The results imply that assessment of semantic memory is relevant in the evaluation of patients with suspected AD.

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DO - http://dx.doi.org/10.1159/000082352

M3 - Journal article

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SP - 75

EP - 81

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

IS - 2-3

ER -

Semantic memory impairment in the earliest phases of Alzheimer's disease

Abstract

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